Integration of high-throughput omics technologies in medicinal plant research: The new era of natural drug discovery

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dc.contributor.authorZhang, Wentingen
dc.contributor.authorZeng, Yuanen
dc.contributor.authorJiao, Mengen
dc.contributor.authorYe, Chanjuanen
dc.contributor.authorLi, Yanrongen
dc.contributor.authorLiu, Chuanguangen
dc.contributor.authorWang, Jihuaen
dc.date.accessioned2023-01-19T13:12:57Zen
dc.date.available2023-01-19T13:12:57Zen
dc.date.issued2023-01-18en
dc.date.updated2023-01-18T18:13:30Zen
dc.description.abstractMedicinal plants are natural sources to unravel novel bioactive compounds to satisfy human pharmacological potentials. The world’s demand for herbal medicines is increasing year by year; however, large-scale production of medicinal plants and their derivatives is still limited. The rapid development of modern technology has stimulated multi-omics research in medicinal plants, leading to a series of breakthroughs on key genes, metabolites, enzymes involved in biosynthesis and regulation of active compounds. Here, we summarize the latest research progress on the molecular intricacy of medicinal plants, including the comparison of genomics to demonstrate variation and evolution among species, the application of transcriptomics, proteomics and metabolomics to explore dynamic changes of molecular compounds, and the utilization of potential resources for natural drug discovery. These multi-omics research provide the theoretical basis for environmental adaptation of medicinal plants and allow us to understand the chemical diversity and composition of bioactive compounds. Many medicinal herbs’ phytochemical constituents and their potential health benefits are not fully explored. Given their large diversity and global distribution as well as the impacts of growth duration and environmental factors on bioactive phytochemicals in medicinal plants, it is crucial to emphasize the research needs of using multi-omics technologies to address basic and applied problems in medicinal plants to aid in developing new and improved medicinal plant resources and discovering novel medicinal ingredients.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fpls.2023.1073848en
dc.identifier.orcidZeng, Yuan [0000-0003-2813-8960]en
dc.identifier.urihttp://hdl.handle.net/10919/113253en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleIntegration of high-throughput omics technologies in medicinal plant research: The new era of natural drug discoveryen
dc.title.serialFrontiers in Plant Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dcterms.dateAccepted2023-01-04en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Southern Piedmont ARECen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen

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