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Adsorption of Blood Proteins onto Polysaccharide Surfaces

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dc.contributor.authorTan, Xinyien
dc.contributor.committeechairRoman, Marenen
dc.contributor.committeememberEdgar, Kevin J.en
dc.contributor.committeememberEsker, Alan R.en
dc.contributor.departmentMacromolecular Science and Engineeringen
dc.date.accessioned2017-07-04T06:00:16Zen
dc.date.available2017-07-04T06:00:16Zen
dc.date.issued2016-01-10en
dc.description.abstractIn this study, surface plasmon resonance (SPR) and quartz crystal microbalance with dissipation monitoring (QCM-D) were combined to investigate the adsorption behavior of two platelet adhesion-related blood proteins, human serum albumin (HSA) and human serum fibrinogen (HSF), on two polysaccharide materials used for hemodialysis membrane applications: regenerated cellulose and cellulose acetate. The study aims to provide insight into the design of novel hemocompatible polysaccharide materials. Information such as real-time adsorption curves, adsorbed amounts, and water contents of the protein layers were obtained and analyzed. The results suggested 1) monolayer adsorption of HSA on both cellulose and cellulose acetate, possibly with different HSA conformations; 2) a multilayer of HSF or some degree of end-on adsorption on both surfaces. The study of HSA adsorption onto cellulose acetate surfaces with different degrees of substitution indicated that the change in content of acetyl groups may not be the main factor governing the adsorbed HSA amount but may affect the conformation of adsorbed HSA molecules.en
dc.description.degreeMaster of Scienceen
dc.format.mediumETDen
dc.identifier.othervt_gsexam:6528en
dc.identifier.urihttp://hdl.handle.net/10919/78309en
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectalbuminen
dc.subjectfibrinogenen
dc.subjectcellulose acetateen
dc.subjectcelluloseen
dc.subjectthin filmsen
dc.subjectadsorptionen
dc.titleAdsorption of Blood Proteins onto Polysaccharide Surfacesen
dc.typeThesisen
thesis.degree.disciplineMacromolecular Science and Engineeringen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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