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The urinary excretion of mercapturic acids in free-living adult males

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dc.contributor.authorChen, Hui-Chuenen
dc.contributor.committeechairWebb, Ryland E.en
dc.contributor.committeememberThye, Forrest W.en
dc.contributor.committeememberBunce, George Edwinen
dc.contributor.departmentHuman Nutrition and Foodsen
dc.date.accessioned2014-03-14T21:51:01Zen
dc.date.adate2009-12-05en
dc.date.available2014-03-14T21:51:01Zen
dc.date.issued1991-12-17en
dc.date.rdate2009-12-05en
dc.date.sdate2009-12-05en
dc.description.abstractIn order to establish a profile of detoxification via glutathione conjugation, the level of urinary mercapturic acid excreted by a free-living male population and the effect of external environmental and genetic factors, such as consumption of vegetables, fruits, and meat, charbroiled food intake, tobacco, alcohol, caffeinated coffee, and marijuana use, exposure to chemicals and familial cancer incidence, were investigated. A subgroup of 30 subjects was randomly selected from 117 subjects who complied with the collection protocol. Three consecutive 24 hr urine samples of this subgroup were analyzed. The modified method of Seutter-Berlage et al (Chemical Porphyria in Man. Elsevier/North-Holland Biomedical Press, N.Y. 1979:233-236) was used for the quantitation of urinary mercapturic acid. The mean excretion of mercapturic acid was 0.27 mmole mercapturate (-SH)/24 hr and 18.1 umole -SH/mmole creatinine. An analysis of variance showed a large degree of inter- and intraindividual variability. The interindividual coefficients of variation in mmole -SH/24 hr and umole -SH/mmole creatinine were 37.7% and 31.2%, respectively. The intraindividual coefficients of variation in mmole -SH/24 hr and umole - SH/mmole creatinine were 32.4% and 30.1%, respectively. A higher (p≤0.05) excretion of mercapturic acid was observed among subjects with a high frequency of exposure to chemicals. The lack of significance of the other dietary, non-dietary, and genetic factors on the observed mercapturic acid excretion may be due to the large inter- and intravariability, the use of food consumption frequency in food intake analysis, and unequal sample sizes of subgroups.en
dc.description.degreeMaster of Scienceen
dc.format.extent79 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-12052009-020010en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-12052009-020010/en
dc.identifier.urihttp://hdl.handle.net/10919/46122en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V855_1991.C545.pdfen
dc.relation.isformatofOCLC# 25402849en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V855 1991.C545en
dc.subject.lcshThiolsen
dc.subject.lcshUrine -- Analysisen
dc.titleThe urinary excretion of mercapturic acids in free-living adult malesen
dc.typeThesisen
dc.type.dcmitypeTexten
thesis.degree.disciplineHuman Nutrition and Foodsen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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