Histotripsy for the Treatment of Cholangiocarcinoma Liver Tumors: In Vivo Feasibility and Ex Vivo Dosimetry Study

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dc.contributor.authorHendricks-Wenger, Alissaen
dc.contributor.authorWeber, Peteren
dc.contributor.authorSimon, Alexen
dc.contributor.authorSaunier, Sofieen
dc.contributor.authorCoutermarsh-Ott, Sherylen
dc.contributor.authorGrider, Douglasen
dc.contributor.authorVidal-Jove, Joanen
dc.contributor.authorAllen, Irving C.en
dc.contributor.authorLuyimbazi, Daviden
dc.contributor.authorVlaisavljevich, Elien
dc.date.accessioned2022-09-23T14:51:55Zen
dc.date.available2022-09-23T14:51:55Zen
dc.date.issued2021-09-01en
dc.date.updated2022-09-22T18:10:01Zen
dc.description.abstractHistotripsy is a noninvasive, nonionizing, and nonthermal focused ultrasound ablation method that is currently being developed for the treatment of liver cancer. Promisingly, histotripsy has been shown for ablating primary [hepatocellular carcinoma (HCC)] and metastatic [colorectal liver metastasis (CLM)] liver tumors in preclinical and early clinical studies. The feasibility of treating cholangiocarcinoma (CC), a less common primary liver tumor that arises from the bile ducts, has not been explored previously. Given that prior work has established that histotripsy susceptibility is based on tissue mechanical properties, there is a need to explore histotripsy as a treatment for CC due to its dense fibrotic stromal components. In this work, we first investigated the feasibility of histotripsy for ablating CC tumors in vivo in a patient-derived xenograft mouse model. The results showed that histotripsy could generate CC tumor ablation using a 1-MHz small animal histotripsy system with treatment doses of 250, 500, and 1000 pulses/point. The second set of experiments compared the histotripsy doses required to ablate CC tumors to HCC and CLM tumors ex vivo. For this, human tumor samples were harvested after surgery and treated ex vivo with a 700-kHz clinical histotripsy transducer. Results demonstrated that significantly higher treatment doses were required to ablate CC and CLM tumors compared to HCC, with the highest treatment dose required for CC tumors. Overall, the results of this study suggest that histotripsy has the potential to be used for the ablation of CC tumors while also highlighting the need for tumor-specific treatment strategies.en
dc.description.versionAccepted versionen
dc.format.extentPages 2953-2964en
dc.format.extent12 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1109/TUFFC.2021.3073563en
dc.identifier.eissn1525-8955en
dc.identifier.issn0885-3010en
dc.identifier.issue9en
dc.identifier.orcidVlaisavljevich, Eli [0000-0002-4097-6257]en
dc.identifier.orcidAllen, Irving [0000-0001-9573-5250]en
dc.identifier.orcidGrider, Douglas [0000-0002-6346-094X]en
dc.identifier.pmid33856990en
dc.identifier.urihttp://hdl.handle.net/10919/111979en
dc.identifier.volume68en
dc.language.isoenen
dc.publisherIEEEen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000690441000015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectTumorsen
dc.subjectTransducersen
dc.subjectLiveren
dc.subjectIn vivoen
dc.subjectMiceen
dc.subjectSurgeryen
dc.subjectProbesen
dc.subjectMedical imagingen
dc.subjectmedical transducersen
dc.subjectsystem & device designen
dc.subjecttherapeuticsen
dc.subjectCAVITATIONAL ULTRASOUND THERAPYen
dc.subjectHEPATOCELLULAR-CARCINOMAen
dc.subjectRADIOFREQUENCY ABLATIONen
dc.subjectINTRINSIC THRESHOLDen
dc.subjectSUSCEPTIBILITYen
dc.subjectELASTOGRAPHYen
dc.subjectMETASTASESen
dc.subjectFEEDBACKen
dc.subjectTISSUESen
dc.subjectTRIALen
dc.subjectBioengineeringen
dc.subjectColo-Rectal Canceren
dc.subjectLiver Diseaseen
dc.subjectRare Diseasesen
dc.subjectDigestive Diseasesen
dc.subjectLiver Canceren
dc.subjectCanceren
dc.subject.meshBile Ducts, Intrahepaticen
dc.subject.meshAnimalsen
dc.subject.meshMiceen
dc.subject.meshCarcinoma, Hepatocellularen
dc.subject.meshCholangiocarcinomaen
dc.subject.meshBile Duct Neoplasmsen
dc.subject.meshLiver Neoplasmsen
dc.subject.meshFeasibility Studiesen
dc.titleHistotripsy for the Treatment of Cholangiocarcinoma Liver Tumors: In Vivo Feasibility and Ex Vivo Dosimetry Studyen
dc.title.serialIEEE Transactions on Ultrasonics Ferroelectrics and Frequency Controlen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Engineeringen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/Engineering/Biomedical Engineering and Mechanicsen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Durelle Scotten
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Basic Scienceen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Basic Science/Basic Scienceen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Basic Science/Basic Science/Secondary Appointment-Basic Scienceen

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