Reflection of Dietary Iodine in the 24 h Urinary Iodine Concentration, Serum Iodine and Thyroglobulin as Biomarkers of Iodine Status: A Pilot Study

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dc.contributor.authorHlucny, Katelynen
dc.contributor.authorAlexander, Brenda M.en
dc.contributor.authorGerow, Kenneth G.en
dc.contributor.authorLarson-Meyer, D. Enetteen
dc.date.accessioned2021-08-09T16:55:28Zen
dc.date.available2021-08-09T16:55:28Zen
dc.date.issued2021-07-23en
dc.date.updated2021-08-06T15:19:04Zen
dc.description.abstractBackground: The iodine status of the US population is considered adequate, but subpopulations remain at risk for iodine deficiency and a biomarker of individual iodine status has yet to be determined. The purpose of this study was to determine whether a 3 day titration diet, providing known quantities of iodized salt, is reflected in 24 h urinary iodine concentration (UIC), serum iodine, and thyroglobulin (Tg). Methods: A total of 10 participants (31.3 ± 4.0 years, 76.1 ± 6.3 kg) completed three, 3 day iodine titration diets (minimal iodine, US RDA, (United States Recommended Daily Allowance), and 3× RDA). The 24 h UIC, serum iodine, and Tg were measured following each diet. The 24 h UIC and an iodine-specific food frequency questionnaire (FFQ) were completed at baseline. Results: UIC increased an average of 19.3 μg/L for every gram of iodized salt consumed and was different from minimal to RDA (<i>p</i> = 0.001) and RDA to 3× RDA diets (<i>p</i> = 0.04). Serum iodine was different from RDA to 3× RDA (<i>p</i> = 0.006) whereas Tg was not responsive to diet. Baseline UIC was associated with iodine intake from milk (r = 0.688, <i>p</i> = 0.028) and fish/seafood (r = 0.646, <i>p</i> = 0.043). Conclusion: These results suggest that 24 h UIC and serum iodine may be reflective of individual iodine status and may serve as biomarkers of iodine status.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHlucny, K.; Alexander, B.M.; Gerow, K.; Larson-Meyer, D.E. Reflection of Dietary Iodine in the 24 h Urinary Iodine Concentration, Serum Iodine and Thyroglobulin as Biomarkers of Iodine Status: A Pilot Study. Nutrients 2021, 13, 2520.en
dc.identifier.doihttps://doi.org/10.3390/nu13082520en
dc.identifier.urihttp://hdl.handle.net/10919/104615en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectiodine statusen
dc.subjectbiomarkersen
dc.subjectvalidationen
dc.subjectnutritional exposureen
dc.subjectdietary biomarkersen
dc.subjectiodine intakeen
dc.subjecturinary iodine concentrationen
dc.subjectserum iodineen
dc.subjectthyroglobulinen
dc.subjectfood frequency questionnaireen
dc.subjectdairy productsen
dc.titleReflection of Dietary Iodine in the 24 h Urinary Iodine Concentration, Serum Iodine and Thyroglobulin as Biomarkers of Iodine Status: A Pilot Studyen
dc.title.serialNutrientsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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