Determinants of dengue virus dispersal in the Americas

Simple item page
dc.contributor.authorAllicock, Orchid M.en
dc.contributor.authorSahadeo, Nikitaen
dc.contributor.authorLemey, Philippeen
dc.contributor.authorAuguste, Albert J.en
dc.contributor.authorSuchard, Marc A.en
dc.contributor.authorRambaut, Andrewen
dc.contributor.authorCarrington, Christine V. F.en
dc.contributor.departmentEntomologyen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.date.accessioned2021-09-23T12:35:48Zen
dc.date.available2021-09-23T12:35:48Zen
dc.date.issued2020-07en
dc.date.updated2021-09-23T12:35:45Zen
dc.description.abstractDengue viruses (DENVs) are classified into four serotypes, each of which contains multiple genotypes. DENV genotypes introduced into the Americas over the past five decades have exhibited different rates and patterns of spatial dispersal. In order to understand factors underlying these patterns, we utilized a statistical framework that allows for the integration of ecological, socioeconomic, and air transport mobility data as predictors of viral diffusion while inferring the phylogeographic history. Predictors describing spatial diffusion based on several covariates were compared using a generalized linear model approach, where the support for each scenario and its contribution is estimated simultaneously from the data set. Although different predictors were identified for different serotypes, our analysis suggests that overall diffusion of DENV-1, -2, and -3 in the Americas was associated with airline traffic. The other significant predictors included human population size, the geographical distance between countries and between urban centers and the density of people living in urban environments.en
dc.description.versionPublished versionen
dc.format.extentPages veaa074en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1093/ve/veaa074en
dc.identifier.eissn2057-1577en
dc.identifier.issn2057-1577en
dc.identifier.issue2en
dc.identifier.orcidAuguste, Albert [0000-0001-9048-0041]en
dc.identifier.otherPMC7772473en
dc.identifier.otherveaa074 (PII)en
dc.identifier.pmid33408877en
dc.identifier.urihttp://hdl.handle.net/10919/105045en
dc.identifier.volume6en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/33408877en
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectBayesian phylogeographyen
dc.subjectdengue virusen
dc.subjecthypothesis testingen
dc.subjectspatial diffusionen
dc.subject0603 Evolutionary Biologyen
dc.subject0605 Microbiologyen
dc.titleDeterminants of dengue virus dispersal in the Americasen
dc.title.serialVirus Evolutionen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherresearch-articleen
dc.type.otherJournal Articleen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Entomologyen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Determinants of dengue virus dispersal in the Americas.pdf
Size:
1.53 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

All Faculty Deposits
Destination Area: Global Systems Science (GSS)
Scholarly Works, Entomology
Scholarly Works, Fralin Life Sciences Institute