Vaccine Effectiveness During an Outbreak of COVID-19 Alpha Variant (B.1.1.7) in a Men’s Correctional Facility in Rural Virginia
dc.contributor.author | Silverman, Rachel A. | en |
dc.contributor.author | Ceci, Alessandro | en |
dc.contributor.author | Cohen, Alasdair | en |
dc.contributor.author | Helmick, Meagan | en |
dc.contributor.author | Short, Erica | en |
dc.contributor.author | Bordwine, Paige | en |
dc.contributor.author | Friedlander, Michael J. | en |
dc.contributor.author | Finkielstein, Carla V. | en |
dc.coverage.country | United States | en |
dc.coverage.state | Virginia | en |
dc.date.accessioned | 2022-06-14T18:58:11Z | en |
dc.date.available | 2022-06-14T18:58:11Z | en |
dc.date.issued | 2022-07 | en |
dc.date.updated | 2022-06-14T17:58:16Z | en |
dc.description.abstract | In April 2021, a COVID-19 outbreak occurred at a correctional facility in rural Virginia, USA. Eighty-four infections were identified among 854 incarcerated persons by facilitywide testing with reverse transcription quantitative PCR (qRT-PCR). We used whole-genome sequencing to link all infections to 2 employees infected with the B.1.1.7α (UK) variant. The relative risk comparing unvaccinated to fully vaccinated persons (mRNA-1273 [Moderna, https:// www.moderna.com]) was 7.8 (95% CI 4.8–12.7), corresponding to a vaccine effectiveness of 87.1% (95% CI 79.0%–92.1%). Average qRT-PCR cycle threshold values were lower, suggesting higher viral loads, among unvaccinated infected than vaccinated cases for the N, E, and S genes. Vaccination was highly effective at preventing SARS-CoV-2 infection in this high-risk setting. This approach can be applied to similar settings to estimate vaccine effectiveness as variants emerge to guide public health strategies during the ongoing pandemic. | en |
dc.description.version | Submitted version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.orcid | Silverman, Rachel [0000-0003-3082-9664] | en |
dc.identifier.orcid | Cohen, Alasdair [0000-0002-9917-8647] | en |
dc.identifier.orcid | Finkielstein, Carla [0000-0002-8417-4643] | en |
dc.identifier.uri | http://hdl.handle.net/10919/110778 | en |
dc.language.iso | en | en |
dc.rights | In Copyright | en |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | en |
dc.subject | COVID-19 | en |
dc.subject | Vaccination | en |
dc.title | Vaccine Effectiveness During an Outbreak of COVID-19 Alpha Variant (B.1.1.7) in a Men’s Correctional Facility in Rural Virginia | en |
dc.type | Article | en |
dc.type.dcmitype | Text | en |
dc.type.other | Article | en |
pubs.organisational-group | /Virginia Tech | en |
pubs.organisational-group | /Virginia Tech/Science | en |
pubs.organisational-group | /Virginia Tech/Science/Biological Sciences | en |
pubs.organisational-group | /Virginia Tech/Veterinary Medicine | en |
pubs.organisational-group | /Virginia Tech/Veterinary Medicine/Population Health Sciences | en |
pubs.organisational-group | /Virginia Tech/University Research Institutes | en |
pubs.organisational-group | /Virginia Tech/University Research Institutes/Fralin Life Sciences | en |
pubs.organisational-group | /Virginia Tech/Faculty of Health Sciences | en |
pubs.organisational-group | /Virginia Tech/All T&R Faculty | en |
pubs.organisational-group | /Virginia Tech/Science/COS T&R Faculty | en |
pubs.organisational-group | /Virginia Tech/Veterinary Medicine/CVM T&R Faculty | en |
pubs.organisational-group | /Virginia Tech/University Research Institutes/Fralin Life Sciences/Durelle Scott | en |
pubs.organisational-group | /Virginia Tech/VT Carilion School of Medicine | en |
pubs.organisational-group | /Virginia Tech/VT Carilion School of Medicine/Psychiatry and Behavioral Medicine | en |
pubs.organisational-group | /Virginia Tech/VT Carilion School of Medicine/Psychiatry and Behavioral Medicine/Secondary Appointment-Psychiatry and Behavioral Medicine | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- 22-0091.pdf
- Size:
- 546.82 KB
- Format:
- Adobe Portable Document Format
- Description:
- Submitted version