Concentrations of Conjugated Linoleic Acid Isomers in Human Plasma Reflect Intake of Dairy Products with Enhanced cis-9, trans-11 or tran-10, cis-12 Isomer Content

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dc.contributor.authorShafer, Brian Daviden
dc.contributor.committeechairThye, Forrest W.en
dc.contributor.committeememberNickols-Richardson, Sharon M.en
dc.contributor.committeememberHerbein, Joseph H. Jr.en
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2014-03-14T20:40:55Zen
dc.date.adate2006-09-12en
dc.date.available2014-03-14T20:40:55Zen
dc.date.issued2006-06-20en
dc.date.rdate2009-09-12en
dc.date.sdate2006-06-30en
dc.description.abstractDairy products are a primary source of c9, t11-CLA, an anti-carcinogenic agent, in the diet of humans. The t10, c12-CLA isomer, typically in trace amounts in bovine milk fat, also may benefit human health. Four cows received abomasal infusions of c9, t11-CLA or t10, c12-CLA to obtain milk fat used to prepare butter and yogurt with enhanced c9, t11-CLA or t10, c12-CLA content. Human subjects (3 males, 3 females, ages 22 to 29) received CLA-enhanced butter and yogurt (14% of total kcal) in a crossover study with 2-wk periods. Prior to the study (2 wk) and during a 2-wk washout period between the experimental periods, subjects received butter and yogurt without enhanced CLA content. Blood samples were obtained at 0, 2, 4, 6, and 8 wk relative to the start of the first experimental period. The t10, c12- CLA isomer was detected in plasma (1.32 ug/mL) only when dairy products with enhanced t10, c12-CLA was consumed. Baseline c9, t11-CLA was 6.94 ug/mL plasma during control periods, but increased to 8.95 ug/mL when dairy products with enhanced c9, t11-CLA content were consumed. Results indicated concentrations of CLA isomers in human plasma respond to small changes in daily intake of the isomers in dietary sources.en
dc.description.degreeMaster of Scienceen
dc.identifier.otheretd-06302006-170813en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-06302006-170813/en
dc.identifier.urihttp://hdl.handle.net/10919/33835en
dc.publisherVirginia Techen
dc.relation.haspartCLA_thesis.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectConjugated Linoleic Aciden
dc.subjectPlasma Fatty Acid Concentrationsen
dc.subjectFunctional Fooden
dc.titleConcentrations of Conjugated Linoleic Acid Isomers in Human Plasma Reflect Intake of Dairy Products with Enhanced cis-9, trans-11 or tran-10, cis-12 Isomer Contenten
dc.typeThesisen
thesis.degree.disciplineHuman Nutrition, Foods, and Exerciseen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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