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Increasing HIV-1 pretreatment drug resistance among antiretroviral-naive adults initiating treatment between 2006 and 2014 in Nairobi, Kenya

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dc.contributor.authorChung, Michael H.en
dc.contributor.authorSilverman, Rachel A.en
dc.contributor.authorBeck, Ingrid A.en
dc.contributor.authorYatich, Nellyen
dc.contributor.authorDross, Sandraen
dc.contributor.authorMcKernan-Mullin, Jenniferen
dc.contributor.authorBii, Stephenen
dc.contributor.authorTapia, Kennethen
dc.contributor.authorStern, Joshua A.en
dc.contributor.authorChohan, Bhavnaen
dc.contributor.authorSakr, Samah R.en
dc.contributor.authorKiarie, James N.en
dc.contributor.authorFrenkel, Lisa M.en
dc.coverage.cityNairobien
dc.coverage.countryKenyaen
dc.date.accessioned2022-01-13T16:29:44Zen
dc.date.available2022-01-13T16:29:44Zen
dc.date.issued2016-06-19en
dc.date.updated2022-01-13T16:29:42Zen
dc.description.abstractAntiretroviral-naïve adults initiating antiretroviral therapy in Nairobi, Kenya were tested for HIV-1 drug resistance at codons K103N, Y181C, G190A, M184V, and K65R using an oligonucleotide ligation assay. Prevalence of pretreatment drug resistance increased from 3.89% in 2006 to 10.93% in 2014 (P < 0.001), and 95% of those with resistance had at least one nonnucleoside reverse transcriptase inhibitor mutation. Resistance to tenofovir (K65R) was found in 2014 but not in 2006.en
dc.description.versionAccepted versionen
dc.format.extentPages 1680-1682en
dc.format.extent4 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1097/QAD.0000000000001110en
dc.identifier.eissn1473-5571en
dc.identifier.issn0269-9370en
dc.identifier.issue10en
dc.identifier.orcidSilverman, Rachel [0000-0003-3082-9664]en
dc.identifier.pmid27058353en
dc.identifier.urihttp://hdl.handle.net/10919/107613en
dc.identifier.volume30en
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000377419500020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectImmunologyen
dc.subjectInfectious Diseasesen
dc.subjectVirologyen
dc.subjectOLIGONUCLEOTIDE LIGATION ASSAYen
dc.subjectSUB-SAHARAN AFRICAen
dc.subjectTYPE-1en
dc.subjectINDIVIDUALSen
dc.subjectINFECTIONen
dc.subjectROLLOUTen
dc.subject06 Biological Sciencesen
dc.subject11 Medical and Health Sciencesen
dc.subject17 Psychology and Cognitive Sciencesen
dc.subjectVirologyen
dc.subject.meshHumansen
dc.subject.meshHIV-1en
dc.subject.meshHIV Infectionsen
dc.subject.meshAnti-HIV Agentsen
dc.subject.meshPrevalenceen
dc.subject.meshDrug Resistance, Viralen
dc.subject.meshMutation, Missenseen
dc.subject.meshAdulten
dc.subject.meshKenyaen
dc.subject.meshFemaleen
dc.subject.meshMaleen
dc.subject.meshGenotyping Techniquesen
dc.titleIncreasing HIV-1 pretreatment drug resistance among antiretroviral-naive adults initiating treatment between 2006 and 2014 in Nairobi, Kenyaen
dc.title.serialAIDSen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherLetteren
dc.type.otherJournalen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Population Health Sciencesen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen

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