Suspected Drug-induced Liver Injury Due to 6-Mercaptopurine With a Superimposed SARS-CoV-2 Infection in a Patient With B-ALL

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dc.contributor.authorCablay, Koryen
dc.contributor.authorBorowicz, Violet M.en
dc.contributor.authorFulton, Ryanen
dc.date.accessioned2022-03-02T16:27:47Zen
dc.date.available2022-03-02T16:27:47Zen
dc.date.issued2022-01-28en
dc.date.updated2022-03-02T16:27:45Zen
dc.description.abstract6-mercaptopurine is a chemotherapeutic drug that exhibits hepatotoxic effects due to its toxic metabolites. This report describes a case of suspected drug-induced liver injury exacerbated by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A 16-year-old male with very high risk B-cell acute lymphoblastic leukemia was admitted for hyperbilirubinemia 2 months after a 6-mercaptopurine dosage increase and found to have an active SARS-CoV-2 infection. Liver function improved throughout hospitalization and the patient was discharged on allopurinol. Following liver function after a dosage increase of hepatoxic chemotherapy and in a pediatric oncology patient with an active SARS-CoV-2 infection undergoing treatment is vital due to potential liver impact.en
dc.description.versionAccepted versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1097/mph.0000000000002407en
dc.identifier.eissn1536-3678en
dc.identifier.issn1077-4114en
dc.identifier.other00043426-900000000-96674 (PII)en
dc.identifier.pmid35091518en
dc.identifier.urihttp://hdl.handle.net/10919/109008en
dc.language.isoenen
dc.publisherWolters Kluwer Healthen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/35091518en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject1102 Cardiorespiratory Medicine and Haematologyen
dc.subjectOncology & Carcinogenesisen
dc.titleSuspected Drug-induced Liver Injury Due to 6-Mercaptopurine With a Superimposed SARS-CoV-2 Infection in a Patient With B-ALLen
dc.title.serialJournal of Pediatric Hematology/Oncologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournal Articleen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Pediatricsen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Pediatrics/Pediatric Hematology/Oncologyen

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