Dendritic Cells and Antiphospholipid Syndrome: An Updated Systematic Review

Simple item page
dc.contributor.authorTang, Kuo-Tungen
dc.contributor.authorChen, Hsin-Huaen
dc.contributor.authorChen, Tzu-Tingen
dc.contributor.authorBracci, Nicole R.en
dc.contributor.authorLin, Chi-Chienen
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.date.accessioned2021-08-26T18:43:14Zen
dc.date.available2021-08-26T18:43:14Zen
dc.date.issued2021-08-09en
dc.date.updated2021-08-26T13:26:43Zen
dc.description.abstractAntiphospholipid syndrome (APS) is an autoimmune disease characterized by autoreactive B and T cells against β2-glycoprotein I (B2GPI), with vascular thrombosis or obstetrical complications. Dendritic cells (DCs) are crucial in the generation of autoimmunity. Here, we conducted a comprehensive systematic review on the relationship between DC and APS. We performed a literature search of PubMed as of 26 March 2021. A total of 33 articles were extracted. DCs are pivotal in inducing inflammatory responses and orchestrating adaptive immunity. DCs contribute to the local inflammation regarding vascular thrombosis or obstetrical complications. Both B2GPI and antiphospholipid antibodies (aPL) can promote antigen presentation by DCs and the generation or maintenance of autoimmunity. In addition, plasmacytoid DC activation is enhanced by aPL, thereby augmenting the inflammatory response. In line with these findings, DC modulation appears promising as a future treatment for APS. In conclusion, our review indicated the crucial role of DCs in the pathogenesis of APS. Deeper understanding of the complex relationship would help in developing new treatment strategies.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationTang, K.-T.; Chen, H.-H.; Chen, T.-T.; Bracci, N.R.; Lin, C.-C. Dendritic Cells and Antiphospholipid Syndrome: An Updated Systematic Review. Life 2021, 11, 801.en
dc.identifier.doihttps://doi.org/10.3390/life11080801en
dc.identifier.urihttp://hdl.handle.net/10919/104720en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectantiphospholipid syndromeen
dc.subjectautoimmunityen
dc.subjectβ2-glycoprotein Ien
dc.subjectdendritic cellen
dc.subjectimmune toleranceen
dc.titleDendritic Cells and Antiphospholipid Syndrome: An Updated Systematic Reviewen
dc.title.serialLifeen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
life-11-00801.pdf
Size:
704.8 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Journal Articles, Multidisciplinary Digital Publishing Institute (MDPI)
Scholarly Works, Biomedical Sciences and Pathobiology