VTechWorks Repository :: Browsing by Author "Shahab, Shima"

Browsing by Author "Shahab, Shima"

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Bacteria - Hydrogel Interactions: Mechanistic Insights via Microelastography and Deep Learning
Karmarkar, Bhas Niteen (Virginia Tech, 2024-01-05)
Bacteria-based cancer therapy (BBCT) holds immense promise in addressing the limitations in treatment of solid tumors. Bacterial strains used for BBCT are engineered to express therapeutics, facilitate precise navigation within the tumor microenvironment by enhancing bacteria's motility, chemotaxis (movement toward or away from specific chemicals), or other mechanisms that aid in reaching and infiltrating the tumor tissue effectively, and complementing traditional chemotherapy and immunotherapies while minimizing side effects. Bacterial motility not only influences the ability of bacteria to navigate within the tumor but also plays a pivotal role in optimizing drug delivery, treatment efficacy, and minimizing potential obstacles associated with the complex microenvironment of human tissues. However, the current understanding of bacterial motility remains limited. In this thesis, we use a reductionist approach and study bacteria motile behavior within human tissue phantoms (collagen and agar) and the bacteria-hydrogel interactions. Apart from motility, it is important to analyze the mechanical properties of the hydrogels the bacteria interact with as they play a vital role in overall behavior and physics of bacteria movement. To that extent, there exists a gap in our understanding of the viscoelastic properties of hydrogels. Lastly, systematic and comprehensive investigation of bacteria behavior in hydrogels requires tracking of thousands of individual cells. Thus, there is an unmet need to develop new automated techniques to reduce the labor-intensive manual tracking of bacteria in low-contrast hydrogel environments, with feature sizes comparable to that of bacteria. To address these gaps, this thesis proposes a trident approach towards mechanistic understanding of bacteria motility in time-invariant agar and temporally evolving collagen hydrogels to bridge critical gaps in understanding bacterial motile behavior in these media, non-destructive microelastography-based mechanical characterization of hydrogels with less than 4.7% error compared with rheology, and the development of deep learning-enabled automated bacteria tracking tools with 77% precision.
Coupling of experimentally validated electroelastic dynamics and mixing rules formulation for macro-fiber composite piezoelectric structures
Shahab, Shima; Erturk, Alper (2016-11-03)
Piezoelectric structures have been used in a variety of applications ranging from vibration control and sensing to morphing and energy harvesting. In order to employ the effective 33-mode of piezoelectricity, interdigitated electrodes have been used in the design of macro-fiber composites which employ piezoelectric fibers with rectangular cross section. In this article, we present an investigation of the two-way electroelastic coupling (in the sense of direct and converse piezoelectric effects) in bimorph cantilevers that employ interdigitated electrodes for 33-mode operation. A distributedparameter electroelastic modeling framework is developed for the elastodynamic scenarios of piezoelectric power generation and dynamic actuation. Mixing rules (i.e. rule of mixtures) formulation is employed to evaluate the equivalent and homogenized properties of macro-fiber composite structures. The electroelastic and dielectric properties of a representative volume element (piezoelectric fiber and epoxy matrix) between two neighboring interdigitated electrodes are then coupled with the global electro-elastodynamics based on the Euler–Bernoulli kinematics accounting for twoway electromechanical coupling. Various macro-fiber composite bimorph cantilevers with different widths are tested for resonant dynamic actuation and power generation with resistive shunt damping. Excellent agreement is reported between the measured electroelastic frequency response and predictions of the analytical framework that bridges the continuum electro-elastodynamics and mixing rules formulation.
A Data Driven Real Time Control Strategy for Power Management of Plug-in Hybrid Electric Vehicles
Abbaszadeh Chekan, Jafar (Virginia Tech, 2018-05-29)
During the past two decades desperate need for energy-efficient vehicles which has less emission have led to a great attention to and development of electrified vehicles like pure electric, Hybrid Electric Vehicle (HEV) and Plug-in Hybrid Electric Vehicles (PHEVs). Resultantly, a great amount of research efforts have been dedicated to development of control strategies for this type of vehicles including PHEV which is the case study in this thesis. This thesis presents a real-time control scheme to improve the fuel economy of plug-in hybrid electric vehicles (PHEVs) by accounting for the instantaneous states of the system as well as the future trip information. To design the mentioned parametric real-time power management policies, we use dynamic programming (DP). First, a representative power-split PHEV powertrain model is introduced, followed by a DP formulation for obtaining the optimal powertrain trajectories from the energy cost point of view for a given drive cycle. The state and decision variables in the DP algorithm are selected in a way that provides the best tradeoff between the computational time and accuracy which is the first contribution of this research effort. These trajectories are then used to train a set of linear maps for the powertrain control variables such as the engine and electric motor/generator torque inputs, through a least-squares optimization process. The DP results indicate that the trip length (distance from the start of the trip to the next charging station) is a key factor in determining the optimal control decisions. To account for this factor, an additional input variable pertaining to the remaining length of the trip is considered during the training of the real-time control policies. The proposed controller receives the demanded propulsion force and the powertrain variables as inputs, and generates the torque commands for the engine and the electric drivetrain system. Numerical simulations indicate that the proposed control policy is able to approximate the optimal trajectories with a good accuracy using the real-time information for the same drive cycles as trained and drive cycle out of training set. To maintain the battery state-of-charge (SOC) above a certain lower bound, two logics have been introduced a switching logic is implemented to transition to a conservative control policy when the battery SOC drops below a certain threshold. Simulation results indicate the effectiveness of the proposed approach in achieving near-optimal performance while maintaining the SOC within the desired range.
Design and Development of Single Element Focused Ultrasound Transducers
Dodoo, Neffisah Fadillah Naa Darkua (Virginia Tech, 2024-06-11)
Histotripsy is a non-invasive, non-thermal, and non-ionizing therapy that utilizes converging high-pressure ultrasound waves at a focal point to produce cavitation and induce mechanical tissue destruction. Currently, rapid prototyped histotripsy transducers consist of multiple elements and are made using 3D printing methods. Multi-element transducers introduce size constraints and 3D printing has limitations in material choice, cost, and time for larger scale manufacturing. This thesis investigates the development of rapid prototyped single element histotripsy transducers and the use of injection molding for transducer fabrication, utilizing an in-house metal CNC mill for mold manufacturing and a desktop injection molding machine. Nylon 101 and 30% glass-filled nylon were chosen as the plastics to inject as these were found to have the most similar acoustic properties to WaterShed, an ABS-like plastic currently used. Six single-element transducers were constructed with a 2 MHz curved Pz26 piezoceramic disc: two with SLA 3D printed housing, two with SLS 3D printed housing, and two with injection molded housing. Electrical impedance, beam dimensions, focal pressure output, and cavitation were characterized for each element. The results show that rapid prototyped single element transducers can generate enough pressure to perform histotripsy. This marks the development of the first rapid prototyped single element histotripsy transducer and further confirms that injection molding can produce transducers comparable, if not identical or potentially superior, to 3D printed counterparts. Future work aims to further characterize these transducers, explore more material options, and apply injection molding to various transducer designs while optimizing both CNC and injection molding parameters.
Development of Comprehensive Experimental, Analytical and, Numerical Methods for Predicting Rubber Friction and Wear under Thermomechanical Conditions
Shams Kondori, Mehran (Virginia Tech, 2021-10-07)
Viscoelastic materials have been used widely in different applications, such as constructing tires, artificial joints, shoe heels, and soles. A study on the different characteristics of viscoelastic materials has always been a matter of interest in order to improve their properties for various applications. In the automotive industry, rubber, as a viscoelastic material, has been used in several subsystems, such as vehicle interior, suspension, steering joints, and tires. The tire and terrain's contact characteristics are among the essential factors for assessing the performance of the tire and the vehicle in general. Friction and tread wear are two of these contact characteristics. Considering the tire's functionality, for most applications, it is desired to have higher friction to have better traction and a lower wear rate to minimize the material loss of the tread. The friction coefficient and the rubber's wear rate depend on various parameters such as rubber material properties, terrain characteristics, temperature (tread and the environment), and the load. To obtain the wear rate and friction of a viscoelastic material, three approaches have been used for this study: Experimental, Analytical, and Numerical. The results obtained using these approaches have been compared and validated. Several test setups have been designed and implemented to study the wear and friction of the rubber experimentally. Also, a new linear friction tester has been designed and manufactured by the author to achieve this project's objectives. The new test setup has several advantages over existing test setups in this field, such as covering a higher range of velocities while maintaining high precision. The designed Linear Friction tester and the modified dynamic friction tester at the CenTiRe laboratory at Virginia Tech were used to measure the rubber's friction and wear for different testing conditions such as different normal loads, different velocities, and various surfaces such asphalt and sandpaper. The data collected by the experiment will later be used for the validation of the developed models. In order to obtain the wear rate of the rubber using the analytical approach, the real contact area and friction of the rubber were calculated using Persson's model. The simulation has created the surface to obtain the friction coefficient and the real contact area. After obtaining the friction coefficient and the real contact area, the rubber's wear rate was calculated using a novel approach by combining the Persson Powdery Rubber Wear model with the Crack Propagation model. The results from the improved model compare well with the results from the original model. For the last step of this project, a Finite Element approach was used for modeling a tread block and round rubber sample. A new semi-empirical model for wear was developed by improving the Archard wear model. The novel approach was implemented to Abaqus by using the Umeshmotion subroutine and adaptive mesh motion (ALE) and subroutine UFric and UFric_Coef in two categories: The Node base method and the Ribbon base method. For finite element modeling, the visco-hyper elastic material model has been used to define the rubber's material properties.
Dynamics of Multi-functional Acoustic Holograms in Contactless Ultrasonic Energy Transfer Systems
Bakhtiari Nejad, Marjan (Virginia Tech, 2020-08-28)
Contactless ultrasonic power transfer (UPT), using piezoelectric transducers, is based on transferring energy using acoustic waves, in which the waves are generated by an acoustic source or transmitter and then transferred through an acoustic medium such as water or human tissue to a sensor or receiver. The receiver then converts the mechanical strain induced by the incident acoustic waves to electricity and delivers to an electrical load, in which the electrical power output of the system can be determined. The execution and efficiency of this technology can be significantly enhanced through patterning, focusing, and localization of the transmitted acoustic energy in space to simultaneously power pre-determined distributed sensors or devices. A passive 3D-printed acoustic hologram plate alongside a single transducer can generate arbitrary and pre-designed ultrasound fields in a particular distance from the hologram mounted on the transmitter, i.e., a target plane. This dissertation presents the use of these simple, cost-effective, and high-fidelity acoustic holograms in UPT systems to selectively enhance and pattern the electrical power output from the receivers. Different holograms are numerically designed to create single and multi-focal pressure patterns in a target plane where an array of receivers are placed. The incident sound wave from a transmitter, after passing through the hologram, is manipulated, hence, the output field is the desired pressure field, which excites the receivers located at the pre-determined focal points more significantly. Furthermore, multi-functional holograms are designed to generate multiple images at different target planes and driving frequencies, called, respectively, multi-image-plane and multi-frequency patterning holograms. The multiple desired pressure distributions are encoded on the single hologram plate and each is reconstructed by changing the axial distance and by switching the frequency. Several proof-of-concept experiments are performed to verify the functionality of the computationally designed holograms, which are fabricated using modern 3D-printers, i.e., the desired wavefronts are encoded in the hologram plates' thickness profile, being input to the 3D-printer. The experiments include measurement of output pressure fields in water using needle hydrophones and acquisition of receivers' voltage output in UPT systems. Another technique investigated in this dissertation is the implementation of acoustic impedance matching layers deposited on the front leading surface of the transmitter and receiver transducers. Current UPT systems suffer from significant acoustic losses through the transmission line from a piezoelectric transmitter to an acoustic medium and then to a piezoelectric receiver. This is due to the unfavorable acoustic impedance mismatch between the transducers and the medium, which causes a narrow transducer bandwidth and a considerable reflection of the acoustic pressure waves at the boundary layers. Using matching layers enhance the acoustic power transmission into the medium and then reinforce the input as an excitation into the receiver. Experiments are performed to identify the input acoustic pressure from a cylindrical transmitter to a receiver disk operating in the 33-mode of piezoelectricity. Significant enhancements are obtained in terms of the receiver's electrical power output when implementing a two-layer matching structure. A design platform is also developed that can facilitate the construction of high-fidelity acoustically matched transducers, that is, the material layers' selection and determination of their thicknesses. Furthermore, this dissertation presents a numerical analysis for the dynamical motions of a high-intensity focused ultrasound (HIFU)-excited microbubble or stable acoustic cavitation, which includes the effects of acoustic nonlinearity, diffraction, and absorption of the medium, and entails the problem of several biomedical ultrasound applications. Finally, the design and use of acoustic holograms in microfluidic channels are addressed which opens the door of acoustic patterning in particle and cell sorting for medical ultrasound systems.
Dynamics of smart materials in high intensity focused ultrasound field
Bhargava, Aarushi (Virginia Tech, 2020-05-06)
Smart materials are intelligent materials that change their structural, chemical, mechanical, or thermal properties in response to an external stimulus such as heat, light, and magnetic and electric fields. With the increase in usage of smart materials in many sensitive applications, the need for a remote, wireless, efficient, and biologically safe stimulus has become crucial. This dissertation addresses this requirement by using high intensity focused ultrasound (HIFU) as the external trigger. HIFU has a unique capability of maintaining both spatial and temporal control and propagating over long distances with reduced losses, to achieve the desired response of the smart material. Two categories of smart materials are investigated in this research; shape memory polymers (SMPs) and piezoelectric materials. SMPs have the ability to store a temporary shape and returning to their permanent or original shape when subjected to an external trigger. On the other hand, piezoelectric materials have the ability to convert mechanical energy to electrical energy and vice versa. Due to these extraordinary properties, these materials are being used in several industries including biomedical, robotic, noise-control, and aerospace. This work introduces two novel concepts: First, HIFU actuation of SMP-based drug delivery capsules as an alternative way of achieving controlled drug delivery. This concept exploits the pre-determined shape changing capabilities of SMPs under localized HIFU exposure to achieve the desired drug delivery rate. Second, solving the existing challenge of low efficiency by focusing the acoustic energy on piezoelectric receivers to transfer power wirelessly. The fundamental physics underlying these two concepts is explored by developing comprehensive mathematical models that provide an in-depth analysis of individual parameters affecting the HIFU-smart material systems, for the first time in literature. Many physical factors such as acoustic, material and dynamical nonlinearities, acoustic standing waves, and mechanical behavior of materials are explored to increase the developed models' accuracy. These mathematical frameworks are designed with the aim of serving as a basic groundwork for building more complex smart material-based systems under HIFU exposure.
Effects of Nonlinear Propagation of Focused Ultrasound on the Stable Cavitation of a Single Bubble
Bakhtiari-Nejad, Marjan; Shahab, Shima (MDPI, 2018-12-06)
Many biomedical applications such as ultrasonic targeted drug delivery, gene therapy, and molecular imaging entail the problems of manipulating microbubbles by means of a high-intensity focused ultrasound (HIFU) pressure field; namely stable cavitation. In high-intensity acoustic field, bubbles demonstrate translational instability, the well-known erratic dancing motion, which is caused by shape oscillations of the bubbles that are excited by their volume oscillations. The literature of bubble dynamics in the HIFU field is mainly centered on experiments, lacking a systematic study to determine the threshold for shape oscillations and translational motion. In this work, we extend the existing multiphysics mathematical modeling platform on bubble dynamics for taking account of (1) the liquid compressibility which allows us to apply a high-intensity acoustic field; (2) the mutual interactions of volume pulsation, shape modes, and translational motion; as well as (3) the effects of nonlinearity, diffraction, and absorption of HIFU to incorporate the acoustic nonlinearity due to wave kinematics or medium—all in one model. The effects of acoustic nonlinearity on the radial pulsations, axisymmetric modes of shape oscillations, and translational motion of a bubble, subjected to resonance and off-resonance excitation and various acoustic pressure, are examined. The results reveal the importance of considering all the involved harmonics and wave distortion in the bubble dynamics, to accurately predict the oscillations, translational trajectories, and the threshold for inertial (unstable) cavitation. This result is of interest for understanding the bubble dynamical behaviors observed experimentally in the HIFU field.
Electroelastic Modeling and Testing of Direct Contact Ultrasonic Clothes Drying Systems
Dupuis, Eric Donald (Virginia Tech, 2020-07-06)
Energy efficient appliances and devices are becoming increasingly necessary as emissions from electricity production continue to increase the severity of global warming. Many of such appliances have not been substantially redesigned since their creation in the early 1900s. One device in particular which has arguably changed the least and consumes the most energy during use is the electric clothes dryer. The common form of this technology in the United States relies on the generation of thermal energy by passing electrical current through a metal. The resulting heat causes liquid within the clothing to evaporate where humid air is ejected from the control volume. While the conversion of energy from electrical to thermal through a heating element is efficient, the drying characteristics of fabrics in a warm humid environment are not, and much of the heat inside of the dryer does not perform work efficiently. In 2016, researchers at Oak Ridge National Laboratory in Knoxville, Tennessee, proposed an alternative mechanic for the drying of clothes which circumvents the need for thermal energy. This method is called direct-contact ultrasonic clothes drying, utilizing atomization through direct mechanical coupling between mesh piezoelectric transducers and wet fabric. During the atomization process, vertical oscillations of a contained liquid, called Faraday excitations, result in the formation of standing waves on the liquid surface. At increasing amplitudes and frequencies of oscillation, wave peaks become extended and form "necks" connecting small secondary droplets to the bulk liquid. When the oscillation reaches an acceleration threshold, the droplet momentum is sufficient to break the surface tension of the neck and enable the droplets to travel away from the liquid. For smaller drops where surface tension is high, a larger magnitude of acceleration is needed to reach the critical neck lengths necessary for droplet ejection. The various pore sizes within the many fabrics comprising our clothing results in many sizes of droplets retained by the fabric, affecting the rate of atomization due to the differences in surface tension. In this study, we will investigate the physical processes related to the direct contact ultrasonic drying process. Beginning with the electrical actuation of the transducer used in the world's first prototype dryer, we will develop an electromechanical model for predicting the resulting deformation. Various considerations for the material properties and geometry of the transducer will be made for optimizing the output acceleration of the device. Next, the drying rates of fabrics in contact with the transducer will be modeled for identification of parameters which will facilitate timely and energy efficient drying. This task will identify the first ever mechanically coupled drying equation for fabrics in contact with ultrasonic vibrations. The ejection rate of the water atomized by the transducer and passed through microchannels to facilitate drying will then be physically investigated to determine characteristics which may improve mass transport. Finally, future considerations and recommendations for the development of ultrasonic drying will be made as a result of the insight gained by this investigation.
Exploration of Vibrational Control of Two Underactuated Mechanical Systems
Ahmed, Zakia (Virginia Tech, 2022-08-31)
Control of underactuated mechanical systems is of interest as it allows for control authority over all of a system's degrees of freedom without requiring actuation of the full system. In addition to this, open-loop control of a system provides the advantage of applying to systems with unmeasurable states or where sensor integration is not feasible. Vibrational control is an open-loop control strategy that uses high-frequency, high-amplitude forcing to control underactuated mechanical systems. This thesis is concerned with exploring two underactuated mechanical systems that are controlled using vibrational inputs. The first system, a 3 degrees of freedom (DOFs) 2-link mechanism with 1 actuated DOF which is an example of a vibrational control system with 1 input and 2 unactuated DOFs, is used to review analytical results of stability analysis using the averaged potential. Theoretical and numerical results are presented for the achievable stable configurations of the system and the effects of changing the physical parameters on the achievable stable configurations are studied. The primary contribution of this effort is the development of an experimental apparatus where vibrational control is implemented. The second system is a 4DOF system composed of a 2DOF spherical pendulum supported by an actuated 2DOF cart used to study the effects of multiple vibrational inputs acting on a system. Theoretical and numerical analysis results are presented for three variants of harmonic forcing applied to the two actuated degrees of freedom: 1) identical input waveforms, except for the amplitudes, 2) identical input waveforms, except for the amplitudes and a phase shift, and 3) identical input waveforms, but at different frequencies and amplitudes. The equilibrium sets under open-loop vibrational forcing are determined for all three cases. A general closed-loop vibrational control scheme is presented using proportional feedback of the unactuated coordinates superposed with the zero-mean, $T$-periodic vibrational input.
Field Evaluation of Doppler LIDAR Sensors for Early Assessment of Track Instability
Larson, Ian Alexander (Virginia Tech, 2023-05-25)
The primary purpose of this study is to evaluate the use of Doppler Lidar sensors for assessing track weakening that would indicate early stages of track instability. Such track weakening could lead to gage widening or track buckling due to rail thermal expansion. A series of tests are performed at the Transportation Technology Center's High Tonnage Loop, where two sections of track are "doctored" to have weaker lateral strength, one on a tangent and another one in a curve. Multiple tests are performed at speeds ranging from 10 – 40 mph, during which the lateral and vertical deflections of the rail are measured under the weight of the passing wheels of a heavily-loaded gondola. The track weakness is created by removing the rail spikes from eight consecutive ties. The measurements from the soft sections are compared with a track section on a tangent that is determined to have nominally sufficient ("good") stiffness. The measurement system consists of four Doppler Lidar units, two oriented toward the rail gage face to measure lateral rail movement, and two directed to the top of the rail to measure vertical rail movement. The combination of the vertical and lateral measurements is used as an indicator of a lack of rail stability if larger-than-normal movement of the rail is detected in either direction. The data collected is analyzed through various methods designed to differentiate sections of track including Gaussian Mixture Model sorting algorithms, inspection via Short Time Fourier Transforms, Discrete Wavelet Transforms, and manual inspection. None of the methods can be done automatically; they each require a different amount of setup and pre-processing before the raw data can be made suitable for the analysis offered by each. The pre-processing can account for dropped data and can be used to identify some false positives such as switches or lubricators. The test results indicate that the system provides a distinctly different measurement in the sections that are doctored to have less track stability than the section with nominally sufficient stiffness. The detection of the loose track in the tangent sections, however, proves to be less reliable. For those, a mostly ad hoc approach is necessary to match the measured data with video images to pinpoint the exact location of the measurements. It is not clear to what extent such approaches would be feasible in practice. Further evaluations of the test data may be used to shed more light on practical analysis methods—possibly wavelets—that are more automated and less ad hoc. They can also provide alternative system setups or designs of experiments for future tests at TTC or on revenue service tracks.
Focused ultrasound actuation of shape memory polymers; acoustic-thermoelastic modeling and testing
Bhargava, Aarushi; Peng, Kaiyuan; Stieg, Jerry; Mirzaeifar, Reza; Shahab, Shima (The Royal Society of Chemistry, 2017-09-18)
Controlled drug delivery (CDD) technologies have received extensive attention recently. Despite recent efforts, drug releasing systems still face major challenges in practice, including low efficiency in releasing the pharmaceutical compounds at the targeted location with a controlled time rate. We present an experimentally-validated acoustic-thermoelastic mathematical framework for modeling the focused ultrasound (FU)-induced thermal actuation of shape memory polymers (SMPs). This paper also investigates the feasibility of using SMPs stimulated by FU for designing CDD systems. SMPs represent a new class of materials that have gained increased attention for designing biocompatible devices. These polymers have the ability of storing a temporary shape and returning to their permanent or original shape when subjected to external stimuli such as heat. In this work, FU is used as a trigger for noninvasively stimulating SMP-based systems. FU has a superior capability to localize the heating effect, thus initiating the shape recovery process only in selected parts of the polymer. The multiphysics model optimizes the design of a SMP-based CDD system through analysis of a filament as a constituting basestructure and quantifies its activation under FU. Experimental validations are performed using a SMP filament submerged in water coupled with the acoustic waves generated by a FU transducer. The modeling results are used to examine and optimize parameters such as medium properties, input power and frequency, location, geometry and chemical composition of the SMP to achieve favorable shape recovery of a potential drug delivery system.
Focused Ultrasound Methods for the treatment of Tendon Injuries
Meduri, Chitra (Virginia Tech, 2023-07-19)
Tendon injuries are prevalent, debilitating and difficult to treat. Common interventions such as anti-inflammatory medication, growth factor injections and surgery are associated with short-term efficacy and long rehabilitation periods. Tendons possess an incomplete healing response which is reparative (scar-mediated) rather than regenerative, resulting in a 'healed' tissue that is mechanically inferior to the native tendon. While it is widely accepted that mechanical-loading based treatments offer long-term symptomatic resolution and improved functionality, the exact mechanisms of action of such mechanotransduction-based healing cascades remain unclear. Nevertheless, there is significant motivation for the development of non-invasive and efficient rehabilitative treatments that mechanically stimulate the injured tendons to achieve functional healing responses. Focused Ultrasound (FUS) methods are an attractive treatment option as they are non-invasive, utilize higher intensities for shorter durations and are targeted to a very specific treatment volume, hence inducing significant bio-effects in the tissue without affecting surrounding structures. Herein, we present a body of work that includes the development of FUS pulsing to precisely target murine Achilles tendons and emphasize distinct bioeffects (thermal-dominant and mechanical-dominant). We investigated the feasibility of applying FUS pulsing to murine Achilles tendons ex vivo and in vivo and demonstrated that FUS can be safely applied without any deleterious effects in the tendons and surrounding tissues. The animals showed no symptoms of distress after multi-session treatments. Overall, results suggest that tendon material properties are not adversely altered by FUS pulsing. Histological analyses showed mild matrix disorganization, suggesting the need for slight modifications in the ultrasound pulsing parameters and treatment durations. When applied to injured tendons, mechanical dominant schemes seemed to drive larger improvements in material properties compared to thermal-dominant pulsing, confirming our original hypothesis that mechanical stimulation may play a bigger role in tendon healing compared to purely thermal-dominant stimulation. Additionally, feasibility of histotripsy ablation in murine Achilles tendons was successfully investigated ex vivo and in vivo and experimentation to further optimize these methods are ongoing. Such (non-thermal) ablative paradigms will be extremely useful when conservative treatment options are unavailable and debridement of scar tissue is warranted to interrupt the degenerative process and stimulate healing. Finally, a pilot investigation into FUS-induced strains was performed to guide our parameter selection process and deliver controlled strains to achieve healing responses (similar to current clinical rehabilitation protocols). We were able confirm that strains between 1% and 6% (or higher) can be induced by manipulating ultrasound treatment parameters. Overall, or results reiterate the potential of FUS in eliciting the desired bioeffects and thus achieve healing in tendons and provide a snapshot of the expected effects of using such pulsing methods to treat tendon injuries.
Fog Harps: Elastocapillarity, Droplet Dynamics, and Optimization
Kowalski, Nicholas Gerald (Virginia Tech, 2021-05-18)
Fog harvesting is emerging as a promising means to ease the water shortage crisis in arid regions of the world with ample fog. The current state-of-the-art for fog harvesting is mesh netting, which is accessible yet struggles from a dual constraint: a course mesh lets most microscopic fog droplets pass through it, while a fine mesh clogs. In recent years, fog harps have been gaining attention as a superior alternative to meshes, bypassing these inherent constraints. In this work, we expand upon previous fog harp research with a focus on optimization. First, we analyze wire tangling in a harp due to capillary forces, resulting in a mathematical model that is able to predict when wire tangling will occur. Second, we systematically vary three key parameters of a fog harp (wire material, center-to-center wire pitch, and wire length), arriving at an optimal combination. Finally, we develop a numerical model to describe the dynamics of a fog droplet sliding down a harp wire while coalescing with others littered along it. By applying all knowledge acquired through these studies, the next generation of fog harps will push the performance ceiling of practical fog harvesters higher than ever.
Hydroacoustic Parametric Study of Pile Driving-Induced Anthropogenic Sound
Wojciechowski, Shannon (Virginia Tech, 2024-06-04)
Anthropogenic sound in Florida's waters and coastal waterways is most commonly caused by overwater development, marine traffic, and military activity. Overwater construction has increased over the years as a result of aging infrastructure and rising expansions around the United States, including more than forty US Naval facilities containing tens of thousands of feet of pier. Construction methodology, such as pile driving, has risen in shallow waters to build structures such as bridges, piers, and wind farms, with significant consequences for marine life and the environment. More precisely, pile driving activities generate significant decibel levels in the surrounding marine environment. Measurements taken from hydrophones placed in the water near the construction site indicate that the high sound pressure levels produced may be harmful to marine life and the environment. As a result, standards have been established to help alleviate and decrease the possible harm that high decibel sound levels may produce. However, these additional steps increase the overall cost of the construction project. This thesis focuses on replicating the pile driving process using finite element modeling to hydroacoustic parametric study of pile driving-induced anthropogenic sound in neighboring Florida seas, as well as the possible environmental impact of the state's numerous naval base piers. The modeling predictions can then be used to identify the distance from the pile at which marine life and the environment are no longer adversely affected. In addition, computer modeling can reduce construction costs when compared to on-site sensors and monitoring.
Investigation of a Mobile Damping Robot for Electric Transmission Lines
Choi, Andrew C. (Virginia Tech, 2023-07-03)
Electric transmission lines suffer from many hazards, including wind-induced vibrations (WIV), which can lead to fatigue failure of the transmission conductors. Current vibration mitigation methods do not adequately address WIV because they overwhelmingly rely on narrow-band fixed absorbers. A mobile damping robot (MDR) can overcome the limitations of these fixed absorbers by actively transporting them to locations of highest amplitude on the cable; i.e., antinodes. These antinodes are where the absorbers can most efficiently remove energy from the system. While analyses have been performed for vibration absorbers on transmission line conductors, they have not been in the context of a mobile damping robot (MDR). There is a need to investigate the potential impact of the MDR on a transmission line and the resulting implications for the MDR's development. In this thesis, we explore the dynamics of a power line conductor through finite element analysis (FEA) and modal testing. We perform numerical analysis in MATLAB using equations of motion obtained via Hamilton's Principle. We discuss the design and validation of an appropriate test bench and MDR prototype. We also experimentally investigate the ability of the MDR prototype to transport a mass along a conductor to antinode locations. Experimental results indicate that the damping robot is indeed able to navigate to cable locations of highest amplitude corresponding to antinodes. We then conclude and discuss future work. The insights gained from this research lay a foundation to guide further development of the MDR. Through this work, we are better able to define the operating conditions of the MDR, which will facilitate the creation of a more robust, adaptable control framework for expanded capability.
Investigation on Physics-based Multi-scale Modeling of Contact, Friction, and Wear in Viscoelastic Materials with Application in Rubber Compounds
Emami, Anahita (Virginia Tech, 2018-08-29)
This dissertation aims to contribute towards the understanding and modeling of tribological phenomena of contact, friction, and wear in viscoelastic materials with application in rubber compounds. Tribiological properties of rubber compounds are important for many applications such as tires, shoe heels and soles, wiper blades, artificial joints, O-ring seals, and so on. In all these applications, the objective is to maximize the friction coefficient to avoid slipping and reduce the wear rate to improve the life expectancy and performance of the products. The first topic in this study focuses on a novel multiscale contact theory proposed by Persson and explains the advantages of this theory over other classical contact theories. The shortcomings of this theory are also investigated, and three methods are proposed to improve Persson's original contact model by correcting the approximation of deformation in the contact area. The first method is based on the original Greenwood and Williamson (GW) contact theory, which neglects the effect of elastic coupling between asperities. The second method is based on an improved version of GW theory, which considers the elastic coupling effect of asperities in an approximate way. The third method is based on the distribution of local peaks of asperities, which is particularly suitable to determine the fraction of a skewed height profile involved in tribological processes. This method can be implemented within the framework of other proposed methods. Since the height profiles of rough surfaces studied in this dissertation are approximately normally distributed, the second correction method is applied to the original contact model to calculate the real contact area and friction coefficient. The second topic addresses the theoretical model of hysteresis friction in viscoelastic materials. The multiscale temperature rise of the rubber surface due to hysteresis friction is also modeled and the effect of flash temperature on the real contact area and friction coefficient is studied. Since the hysteresis friction is not the only mechanism involved in the rubber friction, a semi-empirical model is added to the hysteresis model to include the contribution of adhesion and other processes on the real contact area. Based on the improved multiscale contact theory, a pressure-dependent friction model is also developed for viscoelastic materials, which is in good agreement with experimental results. The third topic deals with the theory of stationary crack propagation in viscoelastic materials and the effect of crack tip flash temperature on the instability of crack propagation observed in some experimental results in the literature. Initially, a theoretical model is developed to calculate the tearing energy vs crack tip velocity in a Kelvin-Voigt rubber model. Besides, two coupled iterative algorithms are developed to calculate the temperature field around the crack tip in addition to the tearing energy as a function of crack tip velocity. In this model, the effect of crack tip flash temperature on the tearing energy is considered to update the relation between tearing energy vs crack tip velocity, which also affects the flash temperature. A theoretical model is also developed to calculate the contribution of the hysteresis effect to the tearing energy vs crack tip velocity using the dynamic modulus master curve of a rubber compound. Then, the low-frequency fatigue test results are compared with the theoretical predictions and used in the framework of powdery rubber wear theory to calculate the stationary rubber wear rate due to fatigue crack propagation. Moreover, a sliding friction and wear test set-up, with both indoor and outdoor testing capability, is developed to validate the theoretical models. The experimental results confirm that the theoretical model can successfully predict the friction coefficient when there is no trace of thermochemical degradation on the rubber surface. Investigating the wear mechanism of rubber samples on three different surfaces reveals that the contribution of fatigue wear rate is less important than other wear mechanisms such as abrasive wear due to sharp asperities or thermochemical degradation due to a significant rise of temperature on the contact area. Finally, the correlation between friction coefficient and wear rate on different surfaces is studied, and it is found that the relation between friction and wear rate strongly depends on the dominant wear mechanism, which is determined by the surface characteristics, sliding velocity, normal load, and contact flash temperature.
Mechanics, Design, and Fabrication of Metal-Graphene Composites
Agrawal, Arpit Kumar (Virginia Tech, 2023-06-01)
In the last decade, metal-graphene composites have seen significant progress and have received increasing attention because of graphene's ability to improve the mechanical properties. The main mechanism of improvement in metal graphene composite is based on the impeding of dislocations by graphene sheets. The work includes studying the mechanisms behind the improvement caused by graphene sheets and particles using Molecular Dynamics and Density Functional Theory. Interatomic potentials that play an important role in determining the accuracy of Molecular dynamics simulations are developed for Cu-C, Ni-C, Ti-C, and Ni-Ti-C systems. Nanolayered metal-graphene composites are fabricated and the effect of graphene particles on crack's path are investigated by electron microscopy. The mechanisms behind crack's behavior is investigated by atomistic simulations and by comparing energy release rates. Metallic systems that do not deform by dislocations like metallic glasses, NiTi etc. are reinforced with graphene and are also examined by atomistic simulations. In addition, a novel metal-graphene composite in which the metal matrix undergoes a uniform large recoverable phase transformation when subjected to mechanical loading is proposed and investigated using atomistic simulations. The material has the potential to overcome the long-standing challenge of transferring the extraordinary mechanical performance of nanoscale materials to the bulk level.
Modeling and Analysis of a Cantilever Beam Tip Mass System
Meesala, Vamsi Chandra (Virginia Tech, 2018-05-22)
We model the nonlinear dynamics of a cantilever beam with tip mass system subjected to different excitation and exploit the nonlinear behavior to perform sensitivity analysis and propose a parameter identification scheme for nonlinear piezoelectric coefficients. First, the distributed parameter governing equations taking into consideration the nonlinear boundary conditions of a cantilever beam with a tip mass subjected to principal parametric excitation are developed using generalized Hamilton's principle. Using a Galerkin's discretization scheme, the discretized equation for the first mode is developed for simpler representation assuming linear and nonlinear boundary conditions. We solve the distributed parameter and discretized equations separately using the method of multiple scales. We determine that the cantilever beam tip mass system subjected to parametric excitation is highly sensitive to the detuning. Finally, we show that assuming linearized boundary conditions yields the wrong type of bifurcation. Noting the highly sensitive nature of a cantilever beam with tip mass system subjected to parametric excitation to detuning, we perform sensitivity of the response to small variations in elasticity (stiffness), and the tip mass. The governing equation of the first mode is derived, and the method of multiple scales is used to determine the approximate solution based on the order of the expected variations. We demonstrate that the system can be designed so that small variations in either stiffness or tip mass can alter the type of bifurcation. Notably, we show that the response of a system designed for a supercritical bifurcation can change to yield a subcritical bifurcation with small variations in the parameters. Although such a trend is usually undesired, we argue that it can be used to detect small variations induced by fatigue or small mass depositions in sensing applications. Finally, we consider a cantilever beam with tip mass and piezoelectric layer and propose a parameter identification scheme that exploits the vibration response to estimate the nonlinear piezoelectric coefficients. We develop the governing equations of a cantilever beam with tip mass and piezoelectric layer by considering an enthalpy that accounts for quadratic and cubic material nonlinearities. We then use the method of multiple scales to determine the approximate solution of the response to direct excitation. We show that approximate solution and amplitude and phase modulation equations obtained from the method of multiple scales analysis can be matched with numerical simulation of the response to estimate the nonlinear piezoelectric coefficients.
Multi-functional Holographic Acoustic Lenses for Modulating Low- to High-Intensity Focused Ultrasound
Sallam, Ahmed (Virginia Tech, 2024-03-27)
Focused ultrasound (FUS) is an emerging technology, and it plays an essential role in clinical and contactless acoustic energy transfer applications. These applications have critical criteria for the acoustic pressure level, the creation of complex pressure patterns, spatial management of the complicated acoustic field, and the degree of nonlinear waveform distortion at the focal areas, which have not been met to date. This dissertation focuses on introducing experimentally validated novel numerical approaches, optimization algorithms, and experimental techniques to fill existing knowledge gaps and enhance the functionality of holographic acoustic lenses (HALs) with an emphasis on applications related to biomedical-focused ultrasound and ultrasonic energy transfer. This dissertation also aims to investigate the dynamics of nonlinear acoustic beam shaping in engineered HALs. First, We will introduce 3D-printed metallic acoustic holographic mirrors for precise spatial manipulation of reflected ultrasonic waves. Optimization algorithms and experimental validations are presented for applications like contactless acoustic energy transfer. Furthermore, a portion of the present work focuses on designing holographic lenses in strongly heterogeneous media for ultrasound focusing and skull aberration compensation in transcranial-focused ultrasound. To this end, we collaborated with the Biomedical Engineering and Mechanics Department as well as Fralin Biomedical Research Institute to implement acoustic lenses in transcranial neuromodulation, targeting to improve the quality of life for patients with brain disease by minimizing the treatment time and optimizing the ultrasonic energy into the region of interest. We will also delve into the nonlinear regime for High-Intensity Focused Ultrasound (HIFU) applications, this study is structured under three objectives: (1) establishing nonlinear acoustic-elastodynamics models to represent the dynamics of holographic lenses under low- to high-intensity acoustic fields; (2) validating and leveraging the resulting models for high-fidelity lens designs used in generating specified nonlinear ultrasonic fields of complex spatial distribution; (3) exploiting new physical phenomena in acoustic holography. The performed research in this dissertation yields experimentally proven mathematical frameworks for extending the functionality of holographic lenses, especially in transcranial-focused ultrasound and nonlinear wavefront shaping, advancing knowledge in the burgeoning field of the inverse issue of nonlinear acoustics, which has remained underdeveloped for many years.

Browsing by Author "Shahab, Shima"

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