Increasing HIV-1 pretreatment drug resistance among antiretroviral-naive adults initiating treatment between 2006 and 2014 in Nairobi, Kenya

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Date
2016-06-19
Author
Chung, Michael H.
Silverman, Rachel A.
Beck, Ingrid A.
Yatich, Nelly
Dross, Sandra
McKernan-Mullin, Jennifer
Bii, Stephen
Tapia, Kenneth
Stern, Joshua A.
Chohan, Bhavna
Sakr, Samah R.
Kiarie, James N.
Frenkel, Lisa M.
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Abstract
Antiretroviral-naïve adults initiating antiretroviral therapy in Nairobi, Kenya were tested for HIV-1 drug resistance at codons K103N, Y181C, G190A, M184V, and K65R using an oligonucleotide ligation assay. Prevalence of pretreatment drug resistance increased from 3.89% in 2006 to 10.93% in 2014 (P < 0.001), and 95% of those with resistance had at least one nonnucleoside reverse transcriptase inhibitor mutation. Resistance to tenofovir (K65R) was found in 2014 but not in 2006.
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http://hdl.handle.net/10919/107613
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