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dc.contributor.authorSandal, Indraen_US
dc.contributor.authorBhattacharya, Amitaen_US
dc.contributor.authorSaini, Ukshaen_US
dc.contributor.authorKaur, Devinderen_US
dc.contributor.authorSharma, Shvetaen_US
dc.contributor.authorGulati, Ashuen_US
dc.contributor.authorKumar, Jonnala Ken_US
dc.contributor.authorKumar, Neerajen_US
dc.contributor.authorDayma, Jyotsnaen_US
dc.contributor.authorDas, Pralayen_US
dc.contributor.authorSingh, Bikramen_US
dc.contributor.authorAhuja, Paramvir Sen_US
dc.identifier.citationBMC Chemical Biology. 2011 May 31;11(1):1en_US
dc.description.abstractBackground Accidental autoclaving of L-glutamine was found to facilitate the Agrobacterium infection of a non host plant like tea in an earlier study. In the present communication, we elucidate the structural changes in L-glutamine due to autoclaving and also confirm the role of heat transformed L-glutamine in Agrobacterium mediated genetic transformation of host/non host plants. Results When autoclaved at 121°C and 15 psi for 20 or 40 min, L-glutamine was structurally modified into 5-oxo proline and 3-amino glutarimide (α-amino glutarimide), respectively. Of the two autoclaved products, only α-amino glutarimide facilitated Agrobacterium infection of a number of resistant to susceptible plants. However, the compound did not have any vir gene inducing property. Conclusions We report a one pot autoclave process for the synthesis of 5-oxo proline and α-amino glutarimide from L-glutamine. Xenobiotic detoxifying property of α-amino glutarimide is also proposed.en_US
dc.rightsCreative Commons Attribution 4.0 International*
dc.titleChemical modification of L-glutamine to alpha-amino glutarimide on autoclaving facilitates Agrobacterium infection of host and non-host plants: A new use of a known compounden_US
dc.typeArticle - Refereed
dc.description.versionPeer Reviewed
dc.rights.holderIndra Sandal et al.; licensee BioMed Central Ltd.en_US
dc.title.serialBMC Chemical Biology

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Creative Commons Attribution 4.0 International
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