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dc.contributor.authorParakulsuksatid, Pramuken_US
dc.date.accessioned2014-03-14T20:36:24Z
dc.date.available2014-03-14T20:36:24Z
dc.date.issued2000-04-18en_US
dc.identifier.otheretd-05122000-00440044en_US
dc.identifier.urihttp://hdl.handle.net/10919/32615
dc.description.abstractIn the large-scale production of Saccharomyces cerevisiae (bakerâ s yeast), oxygen transfer, which is one of the major limiting factors, is improved by using high agitation rates. However, high agitation rates subject the microorganisms to high shear stress and caused high power consumption. A microbubble dispersion (MBD) method was investigated to improve oxygen transfer at low agitation rates and thus reduce power consumption and shear stress on the microorganisms. The experiments were conducted at the 1-liter level and subsequently scaled-up to 50-liters using a constant volumetric oxygen transfer coefficient (kLa) method for scaling. In comparison to a conventional air-sparged fermentation, the MBD method considerably improved the cell mass yield, growth rate and power consumption in the50-liter fermentor. Cell mass production in the MBD system at agitation rate of 150 rpm was about the same as those obtained for a conventional air-sparged system agitatid at 500 rpm. Power consumption in the conventional air-sparged system was three-fold that required for the same biomass yield in the MBD system. However, at the 1-liter scale, the MBD system did not show any significant advantage over the air-sparged system because of the high power consumption.en_US
dc.publisherVirginia Techen_US
dc.relation.haspartWholethesis.pdfen_US
dc.rightsI hereby grant to Virginia Tech or its agents the right to archive and to make available my thesis or dissertation in whole or in part in the University Libraries in all forms of media, now or hereafter known. I retain all proprietary rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part of this thesis or dissertation.en_US
dc.subjectbakerâ s yeast fermentationen_US
dc.subjectpilot-scaleen_US
dc.subjectoxygen transferen_US
dc.subjectmicrobubble dispersionen_US
dc.titleUtilization of a Microbubble Dispersion to Increase Oxygen Transfer in Pilot-Scale Bakerâ s Yeast Fermentation Uniten_US
dc.typeThesisen_US
dc.contributor.departmentBiological Systems Engineeringen_US
dc.description.degreeMaster of Scienceen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelmastersen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineBiological Systems Engineeringen_US
dc.contributor.committeechairAgblevor, Foster Aryien_US
dc.contributor.committeememberCundiff, John S.en_US
dc.contributor.committeememberVelander, William H.en_US
dc.contributor.committeememberYousten, Allan A.en_US
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-05122000-00440044/en_US
dc.date.sdate2000-05-12en_US
dc.date.rdate2001-05-12
dc.date.adate2000-05-12en_US


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