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dc.contributor.authorWhite, David Charlesen_US
dc.date.accessioned2014-03-14T21:52:58Z
dc.date.available2014-03-14T21:52:58Z
dc.date.issued1997-08-21en_US
dc.identifier.otheretd-72297-15249en_US
dc.identifier.urihttp://hdl.handle.net/10919/46506
dc.description.abstractA series of 2-alkyl-3-arylpyrido[2,3-d]pyrimidones were synthesized for testing as potential antiepileptic drugs. The goal was to achieve better neurological activity and/or lower toxicity than displayed by a series of 2-alkyl-3-aryl-4(3H)-quinazolinones prepared previously in our research group. From the pharmacological testing data of these target compounds, we have found that the additional nitrogen at the C-8 position of the quinazolinone framework increased the anticonvulsant activity. However, the neurological toxicity increased as well. The anticonvulsant and neurotoxic activity seen in the variuos 2-alkyl side chains and 3-aryl substituents incorporated into these new pyridopyrimidones was consistent with the activity observed with the same substituents on the 4(3H)-quinazolinones. The 3-aryl group consists of various ortho-substituted phenyl rings, while the 2-alkyl chain consists of a 2-(2-aryl-2-oxo)ethyl or 2-arylethenyl group.en_US
dc.publisherVirginia Techen_US
dc.relation.haspartdcw2.pdfen_US
dc.rightsI hereby grant to Virginia Tech or its agents the right to archive and to make available my thesis or dissertation in whole or in part in the University Libraries in all forms of media, now or hereafter known. I retain all proprietary rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part of this thesis or dissertation.en_US
dc.subjectanticonvulsantsen_US
dc.subjectantiepileptic drugsen_US
dc.subjectpyridopyrimidonesen_US
dc.titleSynthesis of 3-Aryl-2-(2-aryl-2-oxoethyl)pyrido[2,3-d]- 4(3H)pyrimidones and 3-Aryl-2-(2-arylethenyl)pyrido[2,3-d]- 4(3H)pyrimidones as Potential Antiepileptic Drugsen_US
dc.typeThesisen_US
dc.contributor.departmentChemistryen_US
dc.description.degreeMaster of Scienceen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelmastersen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineChemistryen_US
dc.contributor.committeechairWolfe, James F.en_US
dc.contributor.committeememberCalter, Michael A.en_US
dc.contributor.committeememberAnderson, Mark R.en_US
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-72297-15249/en_US
dc.date.sdate1997-08-21en_US
dc.date.rdate1998-08-26
dc.date.adate1997-08-26en_US


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