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    Canine Cancer Screening Via Ultraviolet Absorbance And Fluorescence Spectroscopy Of Serum Proteins

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    Downloads: 664
    Date
    2007-01-01
    Author
    Dickerson, Bryan Douglas
    Geist, Brian L.
    Spillman, William B. Jr.
    Robertson, John L.
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    Abstract
    A cost-effective optical cancer screening and monitoring technique was demonstrated in a pilot study of canine serum samples and was patented for commercialization. Compared to conventional blood chemistry analysis methods, more accurate estimations of the concentrations of albumin, globulins, and hemoglobin in serum were obtained by fitting the near UV absorbance and photoluminescence spectra of diluted serum as a linear combination of component reference spectra. Tracking these serum proteins over the course of treatment helped to monitor patient immune response to carcinoma and therapy. For cancer screening, 70% of dogs with clinical presentation of cancer displayed suppressed serum hemoglobin levels (below 20 mg/dL) in combination with atypical serum protein compositions, that is, albumin levels outside of a safe range (from 4 to 8 g/dL) and globulin levels above or below a more normal range (from 1.7 to 3.7 g/dL). Of the dogs that met these criteria, only 20% were given a false positive label by this cancer screening test. (C) 2007 Optical Society of America.
    URI
    http://hdl.handle.net/10919/46878
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    • Scholarly Works, Department of Biomedical Sciences and Pathobiology [337]
    • Scholarly Works, Department of Physics [807]
    • Scholarly Works, School of Biomedical Engineering and Sciences [132]

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