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dc.contributor.authorProkop, Katherine Janeen_US
dc.date.accessioned2015-03-29T06:00:11Z
dc.date.available2015-03-29T06:00:11Z
dc.date.issued2013-10-04en_US
dc.identifier.othervt_gsexam:1641en_US
dc.identifier.urihttp://hdl.handle.net/10919/51655
dc.description.abstractPancreatic and prostate cancer are both prevalent cancers in the United States with pancreatic being one of the most aggressive of all cancers and prostate cancer being one of the most common, ranking as the number one cancer in men. Treatment of both cancers can be quite challenging as the anatomy of the pancreas and prostate, as well as the development and diagnosis of the disease can greatly limit treatment options. Therefore, it is necessary to develop new cancer treatments to help manage and prevent these cancers. Irreversible electroporation is a new non-thermal focal ablation therapy utilizing short, pulsed electric fields to damage cell membranes leading to cell death. The therapy is minimally invasive, involving the insertion of needle electrodes into the region of interest and lasts less than two minutes. Heat sink effects that thermal therapies experience near large blood vessels do not affect irreversible electroporation. This allows the treatment to be used on tumors near vasculature as well as critical structures without harming these vital regions. While irreversible electroporation is a promising new cancer therapy, further developments are necessary to improve treatment planning models. This work aims to further understand the electric field thresholds necessary to kill different types of cancer cells with a focus on pancreatic and prostate cancer. The work is done using an in vitro tumor (hydrogel) model as this model is better than traditional cell suspension studies, with added benefits over the immediate use of tissue and animal models.en_US
dc.format.mediumETDen_US
dc.publisherVirginia Techen_US
dc.rightsThis Item is protected by copyright and/or related rights. Some uses of this Item may be deemed fair and permitted by law even without permission from the rights holder(s), or the rights holder(s) may have licensed the work for use under certain conditions. For other uses you need to obtain permission from the rights holder(s).en_US
dc.subjectirreversible electroporationen_US
dc.subjecthydrogelsen_US
dc.subjectpancreatic canceren_US
dc.subjectprostate canceren_US
dc.titleCell Death Characterization In Tumor Constructs Using Irreversible Electroporationen_US
dc.typeThesisen_US
dc.contributor.departmentBiomedical Engineeringen_US
dc.description.degreeMaster of Scienceen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelmastersen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineBiomedical Engineeringen_US
dc.contributor.committeechairDavalos, Rafael V.en_US
dc.contributor.committeememberRobertson, John L.en_US
dc.contributor.committeememberCimini, Danielaen_US


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