Nitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp.

Thumbnail
View/Open
Accepted Version (306.4Kb)
Downloads: 81
Date
2014-05-16
Author
Rasamison, Vincent E.
Rakotondraibe, L. Harinantenaina
Slebodnick, Carla
Brodie, Peggy J.
Ratsimbason, Michael
TenDyke, Karen
Shen, Yongchun
Randrianjanaka, Lucien M.
Kingston, David G. I.
Metadata
Show full item record
Abstract
The new triterpene turranoic acid (1) and thenew N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were isolated from leaves of a Turraea sp. Compounds 1-3 showed weak to moderate in vitro antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum strain FCM29. Compound 1 also displayed weak cytotoxic activity against the non-small lung cancer cell line H522-T1 with an IC50 value of 16.4 μM.
URI
http://hdl.handle.net/10919/74420
Collections