Nitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp.

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Date
2014-05-16
Author
Rasamison, Vincent E.
Rakotondraibe, L. Harinantenaina
Slebodnick, Carla
Brodie, Peggy J.
Ratsimbason, Michael
TenDyke, Karen
Shen, Yongchun
Randrianjanaka, Lucien M.
Kingston, David G. I.
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Abstract
The new triterpene turranoic acid (1) and thenew N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were isolated from leaves of a Turraea sp. Compounds 1-3 showed weak to moderate in vitro antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum strain FCM29. Compound 1 also displayed weak cytotoxic activity against the non-small lung cancer cell line H522-T1 with an IC50 value of 16.4 μM.
URI
http://hdl.handle.net/10919/74420
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