Nitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp.

Date
2014-05-16Author
Rasamison, Vincent E.
Rakotondraibe, L. Harinantenaina
Slebodnick, Carla
Brodie, Peggy J.
Ratsimbason, Michael
TenDyke, Karen
Shen, Yongchun
Randrianjanaka, Lucien M.
Kingston, David G. I.
Metadata
Show full item recordAbstract
The new triterpene turranoic acid (1) and thenew N-containing nor-triterpene turraenine (2), along with triptocallic acid B (3) and esculentoic acid (4) were isolated from leaves of a Turraea sp. Compounds 1-3 showed weak to moderate in vitro antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum strain FCM29. Compound 1 also displayed weak cytotoxic activity against the non-small lung cancer cell line H522-T1 with an IC50 value of 16.4 μM.