Histotripsy Ablation in Preclinical Animal Models of Cancer and Spontaneous Tumors in Veterinary Patients: A Review

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dc.contributor.authorHendricks-Wenger, Alissaen
dc.contributor.authorArnold, Laurenen
dc.contributor.authorGannon, Jessicaen
dc.contributor.authorSimon, Alexen
dc.contributor.authorSingh, Nehaen
dc.contributor.authorSheppard, Hannahen
dc.contributor.authorNagai-Singer, Margaret A.en
dc.contributor.authorImran, Khan Mohammeden
dc.contributor.authorLee, Kihoen
dc.contributor.authorClark-Deener, Sherrieen
dc.contributor.authorByron, Christopher R.en
dc.contributor.authorEdwards, Michael R.en
dc.contributor.authorLarson, Martha M.en
dc.contributor.authorRossmeisl, John H. Jr.en
dc.contributor.authorCoutermarsh-Ott, Sherylen
dc.contributor.authorEden, Kristinen
dc.contributor.authorDervisis, Nikolaos G.en
dc.contributor.authorKlahn, Shawna L.en
dc.contributor.authorTuohy, Joanne L.en
dc.contributor.authorAllen, Irving C.en
dc.contributor.authorVlaisavljevich, Elien
dc.date.accessioned2022-09-26T12:15:24Zen
dc.date.available2022-09-26T12:15:24Zen
dc.date.issued2021-09-03en
dc.date.updated2022-09-23T19:54:00Zen
dc.description.abstractNew therapeutic strategies are direly needed in the fight against cancer. Over the last decade, several tumor ablation strategies have emerged as stand-alone or combination therapies. Histotripsy is the first completely noninvasive, nonthermal, and nonionizing tumor ablation method. Histotripsy can produce consistent and rapid ablations, even near critical structures. Additional benefits include real-time image guidance, high precision, and the ability to treat tumors of any predetermined size and shape. Unfortunately, the lack of clinically and physiologically relevant preclinical cancer models is often a significant limitation with all focal tumor ablation strategies. The majority of studies testing histotripsy for cancer treatment have focused on small animal models, which have been critical in moving this field forward and will continue to be essential for providing mechanistic insight. While these small animal models have notable translational value, there are significant limitations in terms of scale and anatomical relevance. To address these limitations, a diverse range of large animal models and spontaneous tumor studies in veterinary patients have emerged to complement existing rodent models. These models and veterinary patients are excellent at providing realistic avenues for developing and testing histotripsy devices and techniques designed for future use in human patients. Here, we provide a review of animal models used in preclinical histotripsy studies and compare histotripsy ablation in these models using a series of original case reports across a broad spectrum of preclinical animal models and spontaneous tumors in veterinary patients.en
dc.description.notesPMID: 34478363en
dc.description.versionAccepted versionen
dc.format.extentPages 5-26en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1109/TUFFC.2021.3110083en
dc.identifier.eissn1525-8955en
dc.identifier.issn0885-3010en
dc.identifier.issue1en
dc.identifier.orcidVlaisavljevich, Eli [0000-0002-4097-6257]en
dc.identifier.orcidLarson, Martha [0000-0003-4229-5866]en
dc.identifier.orcidClark-Deener, Sherrie [0000-0002-6620-0625]en
dc.identifier.orcidAllen, Irving [0000-0001-9573-5250]en
dc.identifier.orcidDervisis, Nikolaos [0000-0003-2869-1483]en
dc.identifier.orcidEden, Kristin [0000-0001-5309-5830]en
dc.identifier.pmid34478363en
dc.identifier.urihttp://hdl.handle.net/10919/111996en
dc.identifier.volume69en
dc.language.isoenen
dc.publisherIEEEen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000736741000005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectMedical imagingen
dc.subjectmedical transducersen
dc.subjectsystem and device designen
dc.subjecttherapeuticsen
dc.subjectCAVITATIONAL ULTRASOUND THERAPYen
dc.subjectHEPATOCELLULAR-CARCINOMAen
dc.subjectCOMPARATIVE BIOLOGYen
dc.subjectTISSUE STIFFNESSen
dc.subjectVX-2 TUMORen
dc.subjectLIVERen
dc.subjectDOGSen
dc.subjectOSTEOSARCOMAen
dc.subjectFREQUENCYen
dc.subjectPIGSen
dc.subjectCanceren
dc.subject.meshAnimalsen
dc.subject.meshHumansen
dc.subject.meshNeoplasmsen
dc.subject.meshModels, Animalen
dc.subject.meshAblation Techniquesen
dc.subject.meshHigh-Intensity Focused Ultrasound Ablationen
dc.titleHistotripsy Ablation in Preclinical Animal Models of Cancer and Spontaneous Tumors in Veterinary Patients: A Reviewen
dc.title.serialIEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Controlen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dcterms.dateAccepted2021-09-03en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Engineeringen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Large Animal Clinical Sciencesen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Small Animal Clinical Sciencesen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/Engineering/Biomedical Engineering and Mechanicsen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Durelle Scotten
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/VTC Basic Sciences Educationen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Basic Scienceen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Basic Science/Basic Scienceen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/VTC Basic Sciences Education/VTC Basic Sciences Educationen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Basic Science/Basic Science/Secondary Appointment-Basic Scienceen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicine/Secondary Appointment-Internal Medicineen

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