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High intensity focused ultrasound for the treatment of solid tumors: a pilot study in canine cancer patients

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dc.contributor.authorCarroll, Jenniferen
dc.contributor.authorCoutermarsh-Ott, Sherylen
dc.contributor.authorKlahn, Shawna L.en
dc.contributor.authorTuohy, Joanne L.en
dc.contributor.authorBarry, Sabrina L.en
dc.contributor.authorAllen, Irving C.en
dc.contributor.authorHay, Alayna N.en
dc.contributor.authorRuth, Jeffreyen
dc.contributor.authorDervisis, Nikolaos G.en
dc.date.accessioned2022-08-02T19:53:53Zen
dc.date.available2022-08-02T19:53:53Zen
dc.date.issued2022-01en
dc.date.updated2022-08-02T19:11:08Zen
dc.description.abstractPurpose: To investigate the safety, feasibility, and outcomes of High-Intensity Focused Ultrasound (HIFU) for the treatment of solid tumors in a spontaneous canine cancer model. Methods: Dogs diagnosed with subcutaneous solid tumors were recruited, staged and pretreatment biopsies were obtained. A single HIFU treatment was delivered to result in partial tumor ablation using a commercially available HIFU unit. Tumors were resected 3-6 days post HIFU and samples obtained for histopathology and immunohistochemistry. Total RNA was isolated from paired pre and post treated FFPE tumor samples, and quantitative gene expression analysis was performed using the nCounter Canine IO Panel. Results: A total of 20 dogs diagnosed with solid tumors were recruited and treated in the study. Tumors treated included Soft Tissue Sarcoma (<i>n</i> = 15), Mast Cell Tumor (<i>n</i> = 3), Osteosarcoma (<i>n</i> = 1), and Thyroid Carcinoma (<i>n</i> = 1). HIFU was well tolerated with only 1 dog experiencing a clinically significant adverse event. Pathology confirmed the presence of complete tissue ablation at the HIFU targeted site and immunohistochemistry indicated immune cell infiltration at the treated/untreated tumor border. Quantitative gene expression analysis indicated that 28 genes associated with T-cell activation were differentially expressed post-HIFU. Conclusions: HIFU appears to be safe and feasible for the treatment of subcutaneous canine solid tumors, resulting in ablation of the targeted tissue. HIFU induced immunostimulatory changes, highlighting the canine cancer patient as an attractive model for studying the effects of focal ablation therapies on the tumor microenvironment.en
dc.description.versionPublished versionen
dc.format.extentPages 855-864en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1080/02656736.2022.2097323en
dc.identifier.eissn1464-5157en
dc.identifier.issn0265-6736en
dc.identifier.issue1en
dc.identifier.orcidDervisis, Nikolaos [0000-0003-2869-1483]en
dc.identifier.pmid35848421en
dc.identifier.urihttp://hdl.handle.net/10919/111429en
dc.identifier.volume39en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/35848421en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectDogen
dc.subjectHigh-intensity focused ultrasounden
dc.subjectimmunotherapyen
dc.subjectthermal ablationen
dc.subjectRare Diseasesen
dc.subjectCanceren
dc.subject.meshAnimalsen
dc.subject.meshDogsen
dc.subject.meshSarcomaen
dc.subject.meshPilot Projectsen
dc.subject.meshHigh-Intensity Focused Ultrasound Ablationen
dc.subject.meshTumor Microenvironmenten
dc.titleHigh intensity focused ultrasound for the treatment of solid tumors: a pilot study in canine cancer patientsen
dc.title.serialInternational Journal of Hyperthermiaen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournal Articleen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Small Animal Clinical Sciencesen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Durelle Scotten
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicineen
pubs.organisational-group/Virginia Tech/VT Carilion School of Medicine/Internal Medicine/Secondary Appointment-Internal Medicineen

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