Biogenic Amine-Containing 1,4-Naphthoquinones Mediate Extracellular Electron Transfer in Lactiplantibacillus plantarum

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dc.contributor.authorBlackburn, Benjamin T.en
dc.contributor.authorBarton, Josephen
dc.contributor.authorHoernig, Micahen
dc.contributor.authorBrown, Anne M.en
dc.contributor.authorMevers, Emilyen
dc.date.accessioned2026-01-05T18:17:26Zen
dc.date.available2026-01-05T18:17:26Zen
dc.date.issued2025-09-19en
dc.description.abstractLactiplantibacillus plantarum, a lactic acid gut bacterium, uses exogenous quinones to facilitate extracellular electron transfer (EET) via type II NADH dehydrogenase (Ndh2). To probe Ndh2 specificity, we designed and evaluated a library of biogenic amine-substituted 1,4-naphthoquinones in an Ndh2-dependent EET assay. Analysis of mediator Ndh2 binding interactions revealed that activity correlates with key binding interactions. Specifically, mediators containing aromatic substitutions elicit favorable Ndh2 interactions, promoting EET.en
dc.description.versionPublished versionen
dc.format.extentPages 10548-10552en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1021/acs.orglett.5c03438en
dc.identifier.eissn1523-7052en
dc.identifier.issn1523-7060en
dc.identifier.issue37en
dc.identifier.orcidBrown, Anne [0000-0001-6951-8228]en
dc.identifier.orcidMevers, Emily [0000-0001-7986-5610]en
dc.identifier.pmid40920080en
dc.identifier.urihttps://hdl.handle.net/10919/140585en
dc.identifier.volume27en
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/40920080en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subject.meshAminesen
dc.subject.meshNaphthoquinonesen
dc.subject.meshNADH Dehydrogenaseen
dc.subject.meshMolecular Structureen
dc.subject.meshElectron Transporten
dc.titleBiogenic Amine-Containing 1,4-Naphthoquinones Mediate Extracellular Electron Transfer in <i>Lactiplantibacillus plantarum</i>en
dc.title.serialOrganic Lettersen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournal Articleen
pubs.organisational-groupVirginia Techen
pubs.organisational-groupVirginia Tech/Scienceen
pubs.organisational-groupVirginia Tech/Science/Chemistryen
pubs.organisational-groupVirginia Tech/Libraryen
pubs.organisational-groupVirginia Tech/Faculty of Health Sciencesen
pubs.organisational-groupVirginia Tech/All T&R Facultyen
pubs.organisational-groupVirginia Tech/Science/COS T&R Facultyen
pubs.organisational-groupVirginia Tech/Library/Research, Learning, and Informaticsen
pubs.organisational-groupVirginia Tech/Library/Research, Learning, and Informatics/Data Servicesen
pubs.organisational-groupVirginia Tech/Interdisciplinary/Center for the Mathematics of Biosystemsen
pubs.organisational-groupVirginia Tech/Interdisciplinaryen

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