Hypothalamus-adipose tissue crosstalk: neuropeptide Y and the regulation of energy metabolism

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dc.contributor.authorZhang, W.en
dc.contributor.authorCline, Mark A.en
dc.contributor.authorGilbert, Elizabeth R.en
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.date.accessioned2017-01-06T15:49:17Zen
dc.date.available2017-01-06T15:49:17Zen
dc.date.issued2014-06-10en
dc.description.abstractNeuropeptide Y (NPY) is an orexigenic neuropeptide that plays a role in regulating adiposity by promoting energy storage in white adipose tissue and inhibiting brown adipose tissue activation in mammals. This review describes mechanisms underlying NPY’s effects on adipose tissue energy metabolism, with an emphasis on cellular proliferation, adipogenesis, lipid deposition, and lipolysis in white adipose tissue, and brown fat activation and thermogenesis. In general, NPY promotes adipocyte differentiation and lipid accumulation, leading to energy storage in adipose tissue, with effects mediated mainly through NPY receptor sub-types 1 and 2. This review highlights hypothalamus-sympathetic nervous system-adipose tissue innervation and adipose tissue-hypothalamus feedback loops as pathways underlying these effects. Potential sources of NPY that mediate adipose effects include the bloodstream, sympathetic nerve terminals that innervate the adipose tissue, as well as adipose tissue-derived cells. Understanding the role of central vs. peripherally-derived NPY in whole-body energy balance could shed light on mechanisms underlying the pathogenesis of obesity. This information may provide some insight into searching for alternative therapeutic strategies for the treatment of obesity and associated diseases.en
dc.description.versionPublished versionen
dc.format.extent12 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1186/1743-7075-11-27en
dc.identifier.issn1743-7075en
dc.identifier.urihttp://hdl.handle.net/10919/73994en
dc.identifier.volume11en
dc.language.isoenen
dc.publisherBiomed Centralen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000338242000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectNutrition & Dieteticsen
dc.subjectAdipose tissueen
dc.subjectHypothalamusen
dc.subjectneuropeptide Yen
dc.subjectObesityen
dc.subjectSympathetic nervous systemen
dc.subjectThermogenesisen
dc.subjectRECEPTOR ANTISENSE OLIGODEOXYNUCLEOTIDESen
dc.subjectSPONTANEOUS FOOD-INTAKEen
dc.subjectDIET-INDUCED OBESITYen
dc.subjectNERVOUS-SYSTEMen
dc.subjectBODY-WEIGHTen
dc.subjectADIPOCYTE PROLIFERATIONen
dc.subjectSYMPATHETIC ACTIVITYen
dc.subjectSENSORY DENERVATIONen
dc.subjectLIPID-ACCUMULATIONen
dc.subjectMURINE ADIPOCYTESen
dc.titleHypothalamus-adipose tissue crosstalk: neuropeptide Y and the regulation of energy metabolismen
dc.title.serialNutrition & Metabolismen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Animal and Poultry Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen

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