Antiproliferative triterpenoid saponins from Leptaulus citroides Baill. from the Madagascar rain forest

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dc.contributor.authorSu, Qingxien
dc.contributor.authorBrodie, Peggy J.en
dc.contributor.authorLiu, Yixien
dc.contributor.authorMiller, James S.en
dc.contributor.authorAndrianjafy, Naina M.en
dc.contributor.authorAntsiferana, Rabodoen
dc.contributor.authorRasamison, Vincent E.en
dc.contributor.authorKingston, David G. I.en
dc.contributor.departmentChemistryen
dc.contributor.departmentCenter for Drug Discoveryen
dc.date.accessioned2017-01-26T22:18:42Zen
dc.date.available2017-01-26T22:18:42Zen
dc.date.issued2016en
dc.description.abstractBioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill. (Cardiopteridaceae) led to the isolation of ethyl esters of three new triterpenoid saponins (1–3) and the known sesquiterpenoid cinnamosmolide (4). The structures of 1–3 were elucidated by extensive 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 2, and 4 showed moderate cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 2.8, 10.2 and 2.0 lM, respectively.en
dc.description.versionPublished versionen
dc.format.extent31 - 39 (9) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1007/s13659-015-0083-1en
dc.identifier.eissn2192-2209en
dc.identifier.issn2192-2195en
dc.identifier.urihttp://hdl.handle.net/10919/74435en
dc.identifier.volume6en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urihttp://link.springer.com/journal/13659en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderThe Author(s)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleAntiproliferative triterpenoid saponins from Leptaulus citroides Baill. from the Madagascar rain foresten
dc.title.serialNatural Products and Bioprospectingen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Chemistryen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Distinguished Professorsen

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