Retinal-input-induced epigenetic dynamics in the developing mouse dorsal lateral geniculate nucleus

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dc.contributor.authorHe, Jianlinen
dc.contributor.authorXu, Xiguangen
dc.contributor.authorMonavarfeshani, Aboozaren
dc.contributor.authorBanerjee, Sharmien
dc.contributor.authorFox, Michael A.en
dc.contributor.authorXie, Hehuang Daviden
dc.contributor.departmentElectrical and Computer Engineeringen
dc.contributor.departmentBiological Sciencesen
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.contributor.departmentFralin Biomedical Research Instituteen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.contributor.departmentVirginia-Maryland College of Veterinary Medicineen
dc.date.accessioned2019-02-18T14:20:57Zen
dc.date.available2019-02-18T14:20:57Zen
dc.date.issued2019-02-14en
dc.date.updated2019-02-17T04:18:31Zen
dc.description.abstractDNA methylation plays important roles in the regulation of nervous system development and in cellular responses to environmental stimuli such as light-derived signals. Despite great efforts in understanding the maturation and refinement of visual circuits, we lack a clear understanding of how changes in DNA methylation correlate with visual activity in the developing subcortical visual system, such as in the dorsal lateral geniculate nucleus (dLGN), the main retino-recipient region in the dorsal thalamus. Here, we explored epigenetic dynamics underlying dLGN development at ages before and after eye opening in wild-type mice and mutant mice in which retinal ganglion cells fail to form. We observed that development-related epigenetic changes tend to co-localize together on functional genomic regions critical for regulating gene expression, while retinal-input-induced epigenetic changes are enriched on repetitive elements. Enhancers identified in neurons are prone to methylation dynamics during development, and activity-induced enhancers are associated with retinal-input-induced epigenetic changes. Intriguingly, the binding motifs of activity-dependent transcription factors, including EGR1 and members of MEF2 family, are enriched in the genomic regions with epigenetic aberrations in dLGN tissues of mutant mice lacking retinal inputs. Overall, our study sheds new light on the epigenetic regulatory mechanisms underlying the role of retinal inputs on the development of mouse dLGN.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationEpigenetics & Chromatin. 2019 Feb 14;12(1):13en
dc.identifier.doihttps://doi.org/10.1186/s13072-019-0257-xen
dc.identifier.urihttp://hdl.handle.net/10919/87711en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderThe Author(s)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleRetinal-input-induced epigenetic dynamics in the developing mouse dorsal lateral geniculate nucleusen
dc.title.serialEpigenetics & Chromatinen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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