Novel Electrospun Pullulan Fibers Incorporating Hydroxypropyl-β-Cyclodextrin: Morphology and Relation with Rheological Properties

Simple item page
dc.contributor.authorPoudel, Deepaken
dc.contributor.authorSwilley-Sanchez, Sarahen
dc.contributor.authorO'Keefe, Sean F.en
dc.contributor.authorMatson, John B.en
dc.contributor.authorLong, Timothy E.en
dc.contributor.authorFernández-Fraguas, Cristinaen
dc.contributor.departmentFood Science and Technologyen
dc.contributor.departmentChemistryen
dc.contributor.departmentMacromolecules Innovation Instituteen
dc.date.accessioned2020-11-12T17:22:45Zen
dc.date.available2020-11-12T17:22:45Zen
dc.date.issued2020-10-31en
dc.date.updated2020-11-12T14:14:26Zen
dc.description.abstractFibers produced by electrospinning from biocompatible, biodegradable and naturally occurring polymers have potential advantages in drug delivery and biomedical applications because of their unique functionalities. Here, electrospun submicron fibers were produced from mixtures containing an exopolysaccharide (pullulan) and a small molecule with hosting abilities, hydroxypropyl-&beta;-cyclodextrin (HP-&beta;-CD), thus serving as multi-functional blend. The procedure used water as sole solvent and excluded synthetic polymers. Rheological characterization was performed to evaluate the impact of HP-&beta;-CD on pullulan entanglement concentration (C<sub>E</sub>); the relationship with electrospinnability and fiber morphology was investigated. Neat pullulan solutions required three times C<sub>E</sub> (~20% w/v pullulan) for effective electrospinning and formation of bead-free nanofibers. HP-&beta;-CD (30% w/v) facilitated electrospinning, leading to the production of continuous, beadless fibers (average diameters: 853-1019 nm) at lower polymer concentrations than those required in neat pullulan systems, without significantly shifting the polymer C<sub>E</sub>. Rheological, Differential Scanning Calorimetry (DSC) and Dynamic Light Scattering (DLS) measurements suggested that electrospinnability improvement was due to HP-&beta;-CD assisting in pullulan entanglement, probably acting as a crosslinker. Yet, the type of association was not clearly identified. This study shows that blending pullulan with HP-&beta;-CD offers a platform to exploit the inherent properties and advantages of both components in encapsulation applications.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationPoudel, D.; Swilley-Sanchez, S.; O’keefe, S.; Matson, J.; Long, T.; Fernández-Fraguas, C. Novel Electrospun Pullulan Fibers Incorporating Hydroxypropyl-β-Cyclodextrin: Morphology and Relation with Rheological Properties. Polymers 2020, 12, 2558.en
dc.identifier.doihttps://doi.org/10.3390/polym12112558en
dc.identifier.urihttp://hdl.handle.net/10919/100845en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjecthydroxypropyl-β-cyclodextrinen
dc.subjectelectrospinningen
dc.subjectrheologyen
dc.subjectentanglement concentrationen
dc.titleNovel Electrospun Pullulan Fibers Incorporating Hydroxypropyl-β-Cyclodextrin: Morphology and Relation with Rheological Propertiesen
dc.title.serialPolymersen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
polymers-12-02558-v2.pdf
Size:
6.56 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Journal Articles, Multidisciplinary Digital Publishing Institute (MDPI)
Open Access Subvention Fund Articles
Scholarly Works, Chemistry
Scholarly Works, Food Science and Technology
Scholarly Works, Macromolecules Innovation Institute (MII)
Strategic Growth Area: Economical and Sustainable Materials (ESM)