Mechanisms of Blood–Brain Barrier Dysfunction in Traumatic Brain Injury

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dc.contributor.authorCash, Alisonen
dc.contributor.authorTheus, Michelle H.en
dc.date.accessioned2020-05-14T17:48:50Zen
dc.date.available2020-05-14T17:48:50Zen
dc.date.issued2020-05-08en
dc.date.updated2020-05-14T13:56:10Zen
dc.description.abstractTraumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United States with roughly two million TBIs occurring annually. Due to the spectrum of severity and heterogeneity in TBIs, investigation into the secondary injury is necessary in order to formulate an effective treatment. A mechanical consequence of trauma involves dysregulation of the blood–brain barrier (BBB) which contributes to secondary injury and exposure of peripheral components to the brain parenchyma. Recent studies have shed light on the mechanisms of BBB breakdown in TBI including novel intracellular signaling and cell–cell interactions within the BBB niche. The current review provides an overview of the BBB, novel detection methods for disruption, and the cellular and molecular mechanisms implicated in regulating its stability following TBI.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCash, A.; Theus, M.H. Mechanisms of Blood–Brain Barrier Dysfunction in Traumatic Brain Injury. Int. J. Mol. Sci. 2020, 21, 3344.en
dc.identifier.doihttps://doi.org/10.3390/ijms21093344en
dc.identifier.urihttp://hdl.handle.net/10919/98393en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectBlood–brain barrier disruptionen
dc.subjectTBIen
dc.subjectendothelial cellsen
dc.subjectvascular–astrocyte couplingen
dc.subjectaquaporinen
dc.subjectedemaen
dc.titleMechanisms of Blood–Brain Barrier Dysfunction in Traumatic Brain Injuryen
dc.title.serialInternational Journal of Molecular Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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Journal Articles, Multidisciplinary Digital Publishing Institute (MDPI)
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