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Plant essential oils synergize various pyrethroid insecticides and antagonize malathion in Aedes aegypti

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dc.contributor.authorNorris, Edmund J.en
dc.contributor.authorGross, Aaron D.en
dc.contributor.authorBartholomay, Lyric C.en
dc.contributor.authorCoats, J. R.en
dc.date.accessioned2021-10-06T12:17:52Zen
dc.date.available2021-10-06T12:17:52Zen
dc.date.issued2019-12-01en
dc.date.updated2021-10-06T12:17:47Zen
dc.description.abstractPyrethroid resistance is a significant threat to agricultural, urban and public health pest control activities. Because economic incentives for the production of novel active ingredients for the control of public health pests are lacking, this field is particularly affected by the potential failure of pyrethroid-based insecticides brought about by increasing pyrethroid resistance. As a result, innovative approaches are desperately needed to overcome insecticide resistance, particularly in mosquitoes that transmit deadly and debilitating pathogens. Numerous studies have demonstrated the potential of plant essential oils to enhance the efficacy of pyrethroids. The toxicity of pyrethroids combined with plant oils is significantly greater than the baseline toxicity of either oils or pyrethroids applied alone, which suggests there are synergistic interactions between components of these mixtures. The present study examined the potential of eight plant essential oils applied in one of two concentrations (1% and 5%) to enhance the toxicity of various pyrethroids (permethrin, natural pyrethrins, deltamethrin and β-cyfluthrin). The various plant essential oils enhanced the pyrethroids to differing degrees. The levels of enhancement provided by combinations of plant essential oils and pyrethroids in comparison with pyrethroids alone were calculated and synergistic outcomes characterized. Numerous plant essential oils significantly synergized a variety of pyrethroids; type I pyrethroids were synergized to a greater degree than type II pyrethroids. Eight plant essential oils significantly enhanced 24-h mortality rates provided by permethrin and six plant essential oils enhanced 24-h mortality rates obtained with natural pyrethrins. By contrast, only three plant essential plants significantly enhanced the toxicity of deltamethrin and β-cyfluthrin. Of the plant essential oils that enhanced the toxicity of these pyrethroids, some produced varying levels of synergism and antagonism. Geranium, patchouli and Texas cedarwood oils produced the highest levels of synergism, displaying co-toxicity factors of > 100 in some combinations. To assess the levels of enhancement and synergism of other classes of insecticide, malathion was also applied in combination with the plant oils. Significant antagonism was provided by a majority of the plant essential oils applied in combination with this insecticide, which suggests that plant essential oils may act to inhibit the oxidative activation processes within exposed adult mosquitoes.en
dc.description.versionPublished versionen
dc.format.extentPages 453-466en
dc.format.extent14 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/mve.12380en
dc.identifier.eissn1365-2915en
dc.identifier.issn0269-283Xen
dc.identifier.issue4en
dc.identifier.orcidGross, Aaron [0000-0001-7687-8133]en
dc.identifier.pmid31102301en
dc.identifier.urihttp://hdl.handle.net/10919/105182en
dc.identifier.volume33en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000493660400002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectLife Sciences & Biomedicineen
dc.subjectEntomologyen
dc.subjectVeterinary Sciencesen
dc.subjectpyrethroidsen
dc.subjectplant essential oilsen
dc.subjectenhanceen
dc.subjectsynergizeen
dc.subjectmalathionen
dc.subjectPIPERONYL BUTOXIDEen
dc.subjectRESISTANTen
dc.subjectDIPTERAen
dc.subjectACETYLCHOLINESTERASEen
dc.subjectDELTAMETHRINen
dc.subjectINHIBITIONen
dc.subjectTOXICITYen
dc.subjectRECEPTORen
dc.subjectVECTORen
dc.subjectTropical Medicineen
dc.subject06 Biological Sciencesen
dc.subject07 Agricultural and Veterinary Sciencesen
dc.subject11 Medical and Health Sciencesen
dc.subject.meshAnimalsen
dc.subject.meshAedesen
dc.subject.meshPyrethrinsen
dc.subject.meshMalathionen
dc.subject.meshOils, Volatileen
dc.subject.meshInsecticidesen
dc.subject.meshPesticide Synergistsen
dc.subject.meshDose-Response Relationship, Drugen
dc.subject.meshInsecticide Resistanceen
dc.subject.meshFemaleen
dc.titlePlant essential oils synergize various pyrethroid insecticides and antagonize malathion in Aedes aegyptien
dc.title.serialMedical and Veterinary Entomologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2019-04-15en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Entomologyen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen

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Destination Area: Global Systems Science (GSS)
Scholarly Works, Entomology