Orthohepevirus C: An Expanding Species of Emerging Hepatitis E Virus Variants

TR Number

Date

2020-02-25

Journal Title

Journal ISSN

Volume Title

Publisher

MDPI

Abstract

Hepatitis E virus (HEV) is an emerging zoonotic pathogen that has received an increasing amount of attention from virologists, clinicians, veterinarians, and epidemiologists over the past decade. The host range and animal reservoirs of HEV are rapidly expanding and a plethora of emerging HEV variants have been recently identified, some of which have the potential for interspecies infection. In this review, the detection of genetically diverse HEV variants, classified into and presumably associated with the species Orthohepevirus C, currently comprising HEV genotypes C1 and C2, by either serological or molecular approach is summarized. The distribution, genomic variability, and evolution of Orthohepevirus C are analyzed. Moreover, the potential risk of cross-species infection and zoonotic transmission of Orthohepevirus C are discussed.

Description

Keywords

Orthohepevirus C, hepatitis E virus, genetic variability, molecular evolution, host, zoonosis

Citation

Wang, B.; Harms, D.; Yang, X.-L.; Bock, C.-T. Orthohepevirus C: An Expanding Species of Emerging Hepatitis E Virus Variants. Pathogens 2020, 9, 154.