Mathematical Models of Hepatitis B Virus Dynamics during Antiviral Therapy

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dc.contributor.authorCarracedo Rodriguez, Andreaen
dc.contributor.committeechairCiupe, Stanca M.en
dc.contributor.committeememberRossi, John F.en
dc.contributor.committeememberChung, Matthiasen
dc.contributor.departmentMathematicsen
dc.date.accessioned2016-04-22T08:00:17Zen
dc.date.available2016-04-22T08:00:17Zen
dc.date.issued2016-04-21en
dc.description.abstractAntiviral therapy for patients infected with hepatitis B virus is only partially efficient. The field is in high demand for understanding the connections between the virus, immune responses, short-term and long-term drug efficacy and the overall health of the liver. A mathematical model was introduced in 2009 to help elucidate the host-virus dynamics after the start of therapy. The model allows the study of complicated viral patterns observed in HBV patients. In our research, we will analyze this model to determine the biological markers (e.g. liver proliferation, immune responses, and drug efficacy) that determine the different decay patterns. We will also investigate how such markers affect the length of therapy and the amount of liver damage.en
dc.description.degreeMaster of Scienceen
dc.format.mediumETDen
dc.identifier.othervt_gsexam:7628en
dc.identifier.urihttp://hdl.handle.net/10919/70759en
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectMathematical modelingen
dc.subjectHepatitis B treatmenten
dc.subjectViral decay profilesen
dc.titleMathematical Models of Hepatitis B Virus Dynamics during Antiviral Therapyen
dc.typeThesisen
thesis.degree.disciplineMathematicsen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.levelmastersen
thesis.degree.nameMaster of Scienceen

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