Dietary biomarkers: advances, limitations and future directions

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dc.contributor.authorHedrick, Valisa E.en
dc.contributor.authorDietrich, Andrea M.en
dc.contributor.authorEstabrooks, Paul A.en
dc.contributor.authorSavla, Jyoti S.en
dc.contributor.authorSerrano, Elena L.en
dc.contributor.authorDavy, Brenda M.en
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2017-01-08T21:27:26Zen
dc.date.available2017-01-08T21:27:26Zen
dc.date.issued2012-12-14en
dc.description.abstractThe subjective nature of self-reported dietary intake assessment methods presents numerous challenges to obtaining accurate dietary intake and nutritional status. This limitation can be overcome by the use of dietary biomarkers, which are able to objectively assess dietary consumption (or exposure) without the bias of self-reported dietary intake errors. The need for dietary biomarkers was addressed by the Institute of Medicine, who recognized the lack of nutritional biomarkers as a knowledge gap requiring future research. The purpose of this article is to review existing literature on currently available dietary biomarkers, including novel biomarkers of specific foods and dietary components, and assess the validity, reliability and sensitivity of the markers. This review revealed several biomarkers in need of additional validation research; research is also needed to produce sensitive, specific, cost-effective and noninvasive dietary biomarkers. The emerging field of metabolomics may help to advance the development of food/nutrient biomarkers, yet advances in food metabolome databases are needed. The availability of biomarkers that estimate intake of specific foods and dietary components could greatly enhance nutritional research targeting compliance to national recommendations as well as direct associations with disease outcomes. More research is necessary to refine existing biomarkers by accounting for confounding factors, to establish new indicators of specific food intake, and to develop techniques that are cost-effective, noninvasive, rapid and accurate measures of nutritional status.en
dc.description.versionPublished versionen
dc.format.extent14 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1186/1475-2891-11-109en
dc.identifier.issn1475-2891en
dc.identifier.urihttp://hdl.handle.net/10919/74019en
dc.identifier.volume11en
dc.language.isoenen
dc.publisherBiomed Centralen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000315382600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 2.0 Genericen
dc.rights.holderThe Author(s)en
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/en
dc.subjectNutrition & Dieteticsen
dc.subjectDietary biomarkersen
dc.subjectDietary assessmenten
dc.subjectMetabolomicsen
dc.subjectWHOLE-GRAIN WHEATen
dc.subjectCORONARY-HEART-DISEASEen
dc.subjectFREE-LIVING SUBJECTSen
dc.subjectFATTY-ACID INTAKEen
dc.subjectRESVERATROL METABOLITESen
dc.subjectFREQUENCY QUESTIONNAIREen
dc.subjectPLASMA ALKYLRESORCINOLSen
dc.subjectNUTRITIONAL BIOMARKERSen
dc.subjectURINARY BIOMARKERSen
dc.subjectSUGAR CONSUMPTIONen
dc.titleDietary biomarkers: advances, limitations and future directionsen
dc.title.serialNutrition Journalen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Human Nutrition, Foods, & Exerciseen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineeringen
pubs.organisational-group/Virginia Tech/Engineering/Civil & Environmental Engineeringen
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen

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