Biomembrane Structure and Material Properties Studied With Neutron Scattering

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dc.contributor.authorKinnun, Jacob J.en
dc.contributor.authorScott, Haden L.en
dc.contributor.authorAshkar, Ranaen
dc.contributor.authorKatsaras, Johnen
dc.contributor.departmentPhysicsen
dc.contributor.departmentCenter for Soft Matter and Biological Physicsen
dc.date.accessioned2021-08-25T11:58:22Zen
dc.date.available2021-08-25T11:58:22Zen
dc.date.issued2021-04-27en
dc.date.updated2021-08-25T11:58:17Zen
dc.description.abstractCell membranes and their associated structures are dynamical supramolecular structures where different physiological processes take place. Detailed knowledge of their static and dynamic structures is therefore needed, to better understand membrane biology. The structure–function relationship is a basic tenet in biology and has been pursued using a range of different experimental approaches. In this review, we will discuss one approach, namely the use of neutron scattering techniques as applied, primarily, to model membrane systems composed of lipid bilayers. An advantage of neutron scattering, compared to other scattering techniques, is the differential sensitivity of neutrons to isotopes of hydrogen and, as a result, the relative ease of altering sample contrast by substituting protium for deuterium. This property makes neutrons an ideal probe for the study of hydrogen-rich materials, such as biomembranes. In this review article, we describe isotopic labeling studies of model and viable membranes, and discuss novel applications of neutron contrast variation in order to gain unique insights into the structure, dynamics, and molecular interactions of biological membranes. We specifically focus on how small-angle neutron scattering data is modeled using different contrast data and molecular dynamics simulations. We also briefly discuss neutron reflectometry and present a few recent advances that have taken place in neutron spin echo spectroscopy studies and the unique membrane mechanical data that can be derived from them, primarily due to new models used to fit the data.en
dc.description.versionPublished versionen
dc.format.extent16 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifierARTN 642851 (Article number)en
dc.identifier.doihttps://doi.org/10.3389/fchem.2021.642851en
dc.identifier.eissn2296-2646en
dc.identifier.issn2296-2646en
dc.identifier.orcidAshkar, Rana [0000-0003-4075-2330]en
dc.identifier.pmid33987167en
dc.identifier.urihttp://hdl.handle.net/10919/104701en
dc.identifier.volume9en
dc.language.isoenen
dc.publisherFrontiersen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000648894700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectPhysical Sciencesen
dc.subjectChemistry, Multidisciplinaryen
dc.subjectChemistryen
dc.subjectneutron scatteringen
dc.subjectmembrane biophysical propertiesen
dc.subjectlipid domainsen
dc.subjectraftsen
dc.subjectmembrane dynamicsen
dc.subjectMD simulationen
dc.subjectSMALL-ANGLE NEUTRONen
dc.subjectBILAYER STRUCTURE DETERMINATIONen
dc.subjectLARGE UNILAMELLAR VESICLESen
dc.subjectPHOSPHOLIPID FLIP-FLOPen
dc.subjectX-RAYen
dc.subjectLIPID-MEMBRANESen
dc.subjectALPHA-SYNUCLEINen
dc.subjectASYMMETRIC DISTRIBUTIONen
dc.subjectANTIMICROBIAL PEPTIDEen
dc.subjectBIOLOGICAL-MEMBRANESen
dc.titleBiomembrane Structure and Material Properties Studied With Neutron Scatteringen
dc.title.serialFrontiers in Chemistryen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournalen
dcterms.dateAccepted2021-03-16en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Physicsen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen

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