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In vitro performance of lipid-PLGA hybrid nanoparticles as an antigen delivery system: lipid composition matters

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dc.contributor.authorHu, Yunen
dc.contributor.authorEhrich, Marion F.en
dc.contributor.authorFuhrman, Kristelen
dc.contributor.authorZhang, Chenmingen
dc.contributor.departmentBiological Systems Engineeringen
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.contributor.departmentVirginia-Maryland College of Veterinary Medicineen
dc.date.accessioned2017-01-15T15:19:37Zen
dc.date.available2017-01-15T15:19:37Zen
dc.date.issued2014-08-27en
dc.description.abstractDue to the many beneficial properties combined from both poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) and liposomes, lipid-PLGA hybrid NPs have been intensively studied as cancer drug delivery systems, bio-imaging agent carriers, as well as antigen delivery vehicles. However, the impact of lipid composition on the performance of lipid-PLGA hybrid NPs as a delivery system has not been well investigated. In this study, the influence of lipid composition on the stability of the hybrid NPs and in vitro antigen release from NPs under different conditions was examined. The uptake of hybrid NPs with various surface charges by dendritic cells (DCs) was carefully studied. The results showed that PLGA NPs enveloped by a lipid shell with more positive surface charges could improve the stability of the hybrid NPs, enable better controlled release of antigens encapsulated in PLGA NPs, as well as enhance uptake of NPs by DC.en
dc.description.versionPublished versionen
dc.format.extent10 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationNanoscale Research Letters. 2014 Aug 27;9(1):434en
dc.identifier.doihttps://doi.org/10.1186/1556-276X-9-434en
dc.identifier.issn1556-276Xen
dc.identifier.urihttp://hdl.handle.net/10919/74319en
dc.identifier.volume9en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341882500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderYun Hu et al.; licensee BioMed Central Ltd.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectTechnologyen
dc.subjectNanoscience & Nanotechnologyen
dc.subjectMaterials Science, Multidisciplinaryen
dc.subjectPhysics, Applieden
dc.subjectScience & Technology - Other Topicsen
dc.subjectMaterials Scienceen
dc.subjectPhysicsen
dc.subjectHybrid NPen
dc.subjectLipid compositionen
dc.subjectPLGAen
dc.subjectSurface chargeen
dc.subjectVaccineen
dc.subjectAntigen deliveryen
dc.subjectHUMAN DENDRITIC CELLSen
dc.subjectDRUG-DELIVERYen
dc.subjectRELEASE PROFILESen
dc.subjectLIPOSOMESen
dc.subjectPLATFORMen
dc.subjectSIZEen
dc.titleIn vitro performance of lipid-PLGA hybrid nanoparticles as an antigen delivery system: lipid composition mattersen
dc.title.serialNanoscale Research Lettersen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Biological Systems Engineeringen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen

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