Atazanavir Resensitizes Candida auris to Azoles

TR Number
Date
2023-05-17
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Microbiology
Abstract

Candida auris represents an urgent health threat. Here, we identified atazanavir as a potent drug capable of resensitizing C. auris clinical isolates to the activity of azole antifungals. Atazanavir was able to significantly inhibit the efflux pumps, glucose transport, and ATP synthesis of all tested isolates of C. auris. In addition, the combination of itraconazole with atazanavir-ritonavir significantly reduced the burden of azole-resistant C. auris in murine kidneys by 1.3 log10 (95%), compared to itraconazole alone.

Description
Keywords
HIV protease inhibitors, Candida auris, atazanavir, azole resistance, efflux pumps, in vivo disseminated candidiasis mouse model
Citation