Atazanavir Resensitizes Candida auris to Azoles

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dc.contributor.authorElgammal, Yehiaen
dc.contributor.authorSalama, Ehab A.en
dc.contributor.authorSeleem, Mohamed N.en
dc.date.accessioned2023-11-30T18:24:48Zen
dc.date.available2023-11-30T18:24:48Zen
dc.date.issued2023-05-17en
dc.description.abstractCandida auris represents an urgent health threat. Here, we identified atazanavir as a potent drug capable of resensitizing C. auris clinical isolates to the activity of azole antifungals. Atazanavir was able to significantly inhibit the efflux pumps, glucose transport, and ATP synthesis of all tested isolates of C. auris. In addition, the combination of itraconazole with atazanavir-ritonavir significantly reduced the burden of azole-resistant C. auris in murine kidneys by 1.3 log10 (95%), compared to itraconazole alone.en
dc.description.versionAccepted versionen
dc.format.extent5 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1128/aac.01631-22en
dc.identifier.eissn1098-6596en
dc.identifier.issn0066-4804en
dc.identifier.issue5en
dc.identifier.orcidSeleem, Mohamed [0000-0003-0939-0458]en
dc.identifier.pmid37092991en
dc.identifier.urihttps://hdl.handle.net/10919/116714en
dc.identifier.volume67en
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/37092991en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectHIV protease inhibitorsen
dc.subjectCandida aurisen
dc.subjectatazanaviren
dc.subjectazole resistanceen
dc.subjectefflux pumpsen
dc.subjectin vivo disseminated candidiasis mouse modelen
dc.subject.meshAnimalsen
dc.subject.meshMiceen
dc.subject.meshCandidaen
dc.subject.meshAzolesen
dc.subject.meshFluconazoleen
dc.subject.meshItraconazoleen
dc.subject.meshAntifungal Agentsen
dc.subject.meshMicrobial Sensitivity Testsen
dc.subject.meshDrug Resistance, Fungalen
dc.subject.meshAtazanavir Sulfateen
dc.subject.meshCandida aurisen
dc.titleAtazanavir Resensitizes <i>Candida auris</i> to Azolesen
dc.title.serialAntimicrobial Agents and Chemotherapyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen

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