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A Time Course for Susceptibility to Staphylococcus aureus Respiratory Infection during Influenza in a Swine Model

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dc.contributor.authorSmith, E. A.en
dc.contributor.authorKumar, S. R.en
dc.contributor.authorDeventhiran, Jagadeeswaranen
dc.contributor.authorCecere, Thomas E.en
dc.contributor.authorLeRoith, Tanyaen
dc.contributor.authorMcGilliard, M.en
dc.contributor.authorElankumaran, Subbiahen
dc.contributor.authorMullarky, Isis K.en
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.contributor.departmentDairy Scienceen
dc.date.accessioned2017-01-10T21:29:27Zen
dc.date.available2017-01-10T21:29:27Zen
dc.date.issued2011en
dc.description.abstractBacterial superinfections following influenza A virus (IAV) are predominant causes of morbidity in humans. The recent emergence of methicillin-resistant Staphylococcus aureus (MRSA) and highly virulent IAV strains has reduced treatment options. Development of an appropriate animal model to study secondary S. aureus infections may provide important information regarding disease pathogenesis. Pigs are natural hosts to both IAV and S. aureus and have respiratory physiology and immune response comparable to humans. To establish a time course of susceptibility to S. aureus after IAV infection, nursery pigs infected intranasally with IAV were challenged with MRSA at different time points. Lung pathology scores and MRSA CFU were evaluated in dual-infected animals after IAV infection. Flow cytometric analysis of bronchoalveolar lavage fluid indicated differences between treatments. These results demonstrate the appropriateness of an intranasal challenge model in nursery pigs for studying the pathogenesis of IAV and S. aureus coinfection and provide insights into the timeframe for susceptibility of IAV-infected pigs to secondary S. aureus infection.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationElizabeth A. Smith, Sandeep R. P. Kumar, Jagadeeswaran Deventhiran, Thomas E. Cecere, Tanya LeRoith, Mike McGilliard, Subbiah Elankumaran, Isis Kanevsky Mullarky, "A Time Course for Susceptibility to Staphylococcus aureus Respiratory Infection during Influenza in a Swine Model", Influenza Research and Treatment, vol. 2011, Article ID 846910, 10 pages, 2011. https://doi.org/10.1155/2011/846910en
dc.identifier.doihttps://doi.org/10.1155/2011/846910en
dc.identifier.eissn2090-1399en
dc.identifier.urihttp://hdl.handle.net/10919/74226en
dc.identifier.volume2011en
dc.language.isoenen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/23074662en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleA Time Course for Susceptibility to Staphylococcus aureus Respiratory Infection during Influenza in a Swine Modelen
dc.title.serialInfluenza Research and Treatmenten
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Dairy Scienceen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen

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