Monoubiquitination of histone H2B is a crucial regulator of the transcriptome during memory formation
dc.contributor.author | Navabpour, Shaghayegh | en |
dc.contributor.author | Farrell, Kayla | en |
dc.contributor.author | Kincaid, Shannon E. | en |
dc.contributor.author | Omar, Nour | en |
dc.contributor.author | Musaus, Madeline | en |
dc.contributor.author | Lin, Yu | en |
dc.contributor.author | Xie, Hehuang | en |
dc.contributor.author | Jarome, Timothy J. | en |
dc.date.accessioned | 2025-05-09T19:37:32Z | en |
dc.date.available | 2025-05-09T19:37:32Z | en |
dc.date.issued | 2024-03 | en |
dc.description.abstract | Posttranslational modification of histone proteins is critical for memory formation. Recently, we showed that monoubiquitination of histone H2B at lysine 120 (H2Bub) is critical for memory formation in the hippocampus. However, the transcriptome controlled by H2Bub remains unknown. Here, we found that fear conditioning in male rats increased or decreased the expression of 86 genes in the hippocampus but, surprisingly, siRNA-mediated knockdown of the H2Bub ligase, Rnf20, abolished changes in all but one of these genes. These findings suggest that monoubiquitination of histone H2B is a crucial regulator of the transcriptome during memory formation. | en |
dc.description.version | Published version | en |
dc.format.extent | 5 page(s) | en |
dc.format.mimetype | application/pdf | en |
dc.identifier | ARTN a053912 (Article number) | en |
dc.identifier.doi | https://doi.org/10.1101/lm.053912.123 | en |
dc.identifier.eissn | 1549-5485 | en |
dc.identifier.issn | 1072-0502 | en |
dc.identifier.issue | 3 | en |
dc.identifier.orcid | Jarome, Timothy [0000-0001-9189-8992] | en |
dc.identifier.orcid | Xie, Hehuang [0000-0001-5739-1653] | en |
dc.identifier.other | 31/3/a053912 (PII) | en |
dc.identifier.pmid | 38580378 | en |
dc.identifier.uri | https://hdl.handle.net/10919/131412 | en |
dc.identifier.volume | 31 | en |
dc.language.iso | en | en |
dc.publisher | Cold Spring Harbor Laboratory Press | en |
dc.relation.uri | https://www.ncbi.nlm.nih.gov/pubmed/38580378 | en |
dc.rights | Creative Commons Attribution-NonCommercial 4.0 International | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | en |
dc.subject.mesh | Animals | en |
dc.subject.mesh | Rats | en |
dc.subject.mesh | Ubiquitin-Protein Ligases | en |
dc.subject.mesh | Histones | en |
dc.subject.mesh | Memory | en |
dc.subject.mesh | Protein Processing, Post-Translational | en |
dc.subject.mesh | Male | en |
dc.subject.mesh | Ubiquitination | en |
dc.subject.mesh | Transcriptome | en |
dc.title | Monoubiquitination of histone H2B is a crucial regulator of the transcriptome during memory formation | en |
dc.title.serial | Learning & Memory | en |
dc.type | Article - Refereed | en |
dc.type.dcmitype | Text | en |
dc.type.other | Article | en |
dc.type.other | Journal | en |
dcterms.dateAccepted | 2024-03-07 | en |
pubs.organisational-group | Virginia Tech | en |
pubs.organisational-group | Virginia Tech/Agriculture & Life Sciences | en |
pubs.organisational-group | Virginia Tech/Agriculture & Life Sciences/School of Animal Sciences | en |
pubs.organisational-group | Virginia Tech/Veterinary Medicine | en |
pubs.organisational-group | Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiology | en |
pubs.organisational-group | Virginia Tech/Faculty of Health Sciences | en |
pubs.organisational-group | Virginia Tech/All T&R Faculty | en |
pubs.organisational-group | Virginia Tech/Veterinary Medicine/CVM T&R Faculty | en |
pubs.organisational-group | Virginia Tech/Agriculture & Life Sciences/CALS T&R Faculty | en |
pubs.organisational-group | Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiology/Other | en |