Monoubiquitination of histone H2B is a crucial regulator of the transcriptome during memory formation

dc.contributor.authorNavabpour, Shaghayeghen
dc.contributor.authorFarrell, Kaylaen
dc.contributor.authorKincaid, Shannon E.en
dc.contributor.authorOmar, Nouren
dc.contributor.authorMusaus, Madelineen
dc.contributor.authorLin, Yuen
dc.contributor.authorXie, Hehuangen
dc.contributor.authorJarome, Timothy J.en
dc.date.accessioned2025-05-09T19:37:32Zen
dc.date.available2025-05-09T19:37:32Zen
dc.date.issued2024-03en
dc.description.abstractPosttranslational modification of histone proteins is critical for memory formation. Recently, we showed that monoubiquitination of histone H2B at lysine 120 (H2Bub) is critical for memory formation in the hippocampus. However, the transcriptome controlled by H2Bub remains unknown. Here, we found that fear conditioning in male rats increased or decreased the expression of 86 genes in the hippocampus but, surprisingly, siRNA-mediated knockdown of the H2Bub ligase, Rnf20, abolished changes in all but one of these genes. These findings suggest that monoubiquitination of histone H2B is a crucial regulator of the transcriptome during memory formation.en
dc.description.versionPublished versionen
dc.format.extent5 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifierARTN a053912 (Article number)en
dc.identifier.doihttps://doi.org/10.1101/lm.053912.123en
dc.identifier.eissn1549-5485en
dc.identifier.issn1072-0502en
dc.identifier.issue3en
dc.identifier.orcidJarome, Timothy [0000-0001-9189-8992]en
dc.identifier.orcidXie, Hehuang [0000-0001-5739-1653]en
dc.identifier.other31/3/a053912 (PII)en
dc.identifier.pmid38580378en
dc.identifier.urihttps://hdl.handle.net/10919/131412en
dc.identifier.volume31en
dc.language.isoenen
dc.publisherCold Spring Harbor Laboratory Pressen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/38580378en
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subject.meshAnimalsen
dc.subject.meshRatsen
dc.subject.meshUbiquitin-Protein Ligasesen
dc.subject.meshHistonesen
dc.subject.meshMemoryen
dc.subject.meshProtein Processing, Post-Translationalen
dc.subject.meshMaleen
dc.subject.meshUbiquitinationen
dc.subject.meshTranscriptomeen
dc.titleMonoubiquitination of histone H2B is a crucial regulator of the transcriptome during memory formationen
dc.title.serialLearning & Memoryen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2024-03-07en
pubs.organisational-groupVirginia Techen
pubs.organisational-groupVirginia Tech/Agriculture & Life Sciencesen
pubs.organisational-groupVirginia Tech/Agriculture & Life Sciences/School of Animal Sciencesen
pubs.organisational-groupVirginia Tech/Veterinary Medicineen
pubs.organisational-groupVirginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-groupVirginia Tech/Faculty of Health Sciencesen
pubs.organisational-groupVirginia Tech/All T&R Facultyen
pubs.organisational-groupVirginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-groupVirginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-groupVirginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiology/Otheren

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