Endogenous Regulation and Pharmacological Modulation of Sepsis-Induced HMGB1 Release and Action: An Updated Review

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dc.contributor.authorZhu, Cassie Shuen
dc.contributor.authorWang, Weien
dc.contributor.authorQiang, Xiaolingen
dc.contributor.authorChen, Weiqiangen
dc.contributor.authorLan, Xiqianen
dc.contributor.authorLi, Jianhuaen
dc.contributor.authorWang, Haichaoen
dc.contributor.departmentSchool of Plant and Environmental Sciencesen
dc.date.accessioned2021-09-10T16:55:19Zen
dc.date.available2021-09-10T16:55:19Zen
dc.date.issued2021-08-27en
dc.date.updated2021-09-09T13:38:58Zen
dc.description.abstractSepsis remains a common cause of death in intensive care units, accounting for approximately 20% of total deaths worldwide. Its pathogenesis is partly attributable to dysregulated inflammatory responses to bacterial endotoxins (such as lipopolysaccharide, LPS), which stimulate innate immune cells to sequentially release early cytokines (such as tumor necrosis factor (TNF) and interferons (IFNs)) and late mediators (such as high-mobility group box 1, HMGB1). Despite difficulties in translating mechanistic insights into effective therapies, an improved understanding of the complex mechanisms underlying the pathogenesis of sepsis is still urgently needed. Here, we review recent progress in elucidating the intricate mechanisms underlying the regulation of HMGB1 release and action, and propose a few potential therapeutic candidates for future clinical investigations.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationZhu, C.S.; Wang, W.; Qiang, X.; Chen, W.; Lan, X.; Li, J.; Wang, H. Endogenous Regulation and Pharmacological Modulation of Sepsis-Induced HMGB1 Release and Action: An Updated Review. Cells 2021, 10, 2220.en
dc.identifier.doihttps://doi.org/10.3390/cells10092220en
dc.identifier.urihttp://hdl.handle.net/10919/104981en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectsepsisen
dc.subjectpyroptosisen
dc.subjectinnate immune cellsen
dc.subjectantibodiesen
dc.subjectherbal medicineen
dc.subjectacute-phase proteinsen
dc.subjecthemichannelen
dc.subjectinflammasomeen
dc.titleEndogenous Regulation and Pharmacological Modulation of Sepsis-Induced HMGB1 Release and Action: An Updated Reviewen
dc.title.serialCellsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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