Arm-specific dynamics of chromosome evolution in malaria mosquitoes

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dc.contributor.authorSharakhova, Maria V.en
dc.contributor.authorXia, Aien
dc.contributor.authorLeman, Scotland C.en
dc.contributor.authorSharakhov, Igor V.en
dc.contributor.departmentEntomologyen
dc.contributor.departmentStatisticsen
dc.date.accessioned2017-01-05T22:18:25Zen
dc.date.available2017-01-05T22:18:25Zen
dc.date.issued2011-04-07en
dc.description.abstractBackground: The malaria mosquito species of subgenus Cellia have rich inversion polymorphisms that correlate with environmental variables. Polymorphic inversions tend to cluster on the chromosomal arms 2R and 2L but not on X, 3R and 3L in Anopheles gambiae and homologous arms in other species. However, it is unknown whether polymorphic inversions on homologous chromosomal arms of distantly related species from subgenus Cellia nonrandomly share similar sets of genes. It is also unclear if the evolutionary breakage of inversion-poor chromosomal arms is under constraints. Results: To gain a better understanding of the arm-specific differences in the rates of genome rearrangements, we compared gene orders and established syntenic relationships among Anopheles gambiae, Anopheles funestus, and Anopheles stephensi. We provided evidence that polymorphic inversions on the 2R arms in these three species nonrandomly captured similar sets of genes. This nonrandom distribution of genes was not only a result of preservation of ancestral gene order but also an outcome of extensive reshuffling of gene orders that created new combinations of homologous genes within independently originated polymorphic inversions. The statistical analysis of distribution of conserved gene orders demonstrated that the autosomal arms differ in their tolerance to generating evolutionary breakpoints. The fastest evolving 2R autosomal arm was enriched with gene blocks conserved between only a pair of species. In contrast, all identified syntenic blocks were preserved on the slowly evolving 3R arm of An. gambiae and on the homologous arms of An. funestus and An. stephensi. Conclusions: Our results suggest that natural selection favors specific gene combinations within polymorphic inversions when distant species are exposed to similar environmental pressures. This knowledge could be useful for the discovery of genes responsible for an association of inversion polymorphisms with phenotypic variations in multiple species. Our data support the chromosomal arm specificity in rates of gene order disruption during mosquito evolution. We conclude that the distribution of breakpoint regions is evolutionary conserved on slowly evolving arms and tends to be lineage-specific on rapidly evolving arms.en
dc.description.sponsorshipThis work was supported by National Institutes of Health grants 1R21AI081023 and 5R21AI074729 (to I.V.S).en
dc.description.versionPublished versionen
dc.format.extent? - ? (17) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1186/1471-2148-11-91en
dc.identifier.issn1471-2148en
dc.identifier.urihttp://hdl.handle.net/10919/73967en
dc.identifier.volume11en
dc.language.isoenen
dc.publisherBiomed Centralen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000290472600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 2.0 Genericen
dc.rights.holderThe Author(s)en
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/en
dc.subjectEvolutionary Biologyen
dc.subjectGenetics & Heredityen
dc.subjectVECTOR ANOPHELES-FUNESTUSen
dc.subjectINVERSION POLYMORPHISMSen
dc.subjectDROSOPHILA-PSEUDOOBSCURAen
dc.subjectGAMBIAE COMPLEXen
dc.subjectGENE ORDERen
dc.subjectGENOMEen
dc.subjectADAPTATIONen
dc.subjectORGANIZATIONen
dc.subjectDIVERGENCEen
dc.subjectPATTERNSen
dc.titleArm-specific dynamics of chromosome evolution in malaria mosquitoesen
dc.title.serialBMC Evolutionary Biologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Entomologyen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/Science/Statisticsen

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