Antibiotics ameliorate lupus-like symptoms in mice

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dc.contributor.authorMu, Qinghuien
dc.contributor.authorTavella, Vincent J.en
dc.contributor.authorKirby, Jay L.en
dc.contributor.authorCecere, Thomas E.en
dc.contributor.authorChung, Matthiasen
dc.contributor.authorLee, Jiyoungen
dc.contributor.authorLi, Songen
dc.contributor.authorAhmed, Sattar Ansaren
dc.contributor.authorEden, Kristinen
dc.contributor.authorAllen, Irving C.en
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.contributor.departmentMathematicsen
dc.contributor.departmentSchool of Plant and Environmental Sciencesen
dc.contributor.departmentVirginia-Maryland College of Veterinary Medicineen
dc.date.accessioned2017-11-13T19:43:19Zen
dc.date.available2017-11-13T19:43:19Zen
dc.date.issued2017-10-20en
dc.description.abstractGut microbiota and the immune system interact to maintain tissue homeostasis, but whether this interaction is involved in the pathogenesis of systemic lupus erythematosus (SLE) is unclear. Here we report that oral antibiotics given during active disease removed harmful bacteria from the gut microbiota and attenuated SLE-like disease in lupus-prone mice. Using MRL/lpr mice, we showed that antibiotics given after disease onset ameliorated systemic autoimmunity and kidney histopathology. They decreased IL-17-producing cells and increased the level of circulating IL-10. In addition, antibiotics removed Lachnospiraceae and increased the relative abundance of Lactobacillus spp., two groups of bacteria previously shown to be associated with deteriorated or improved symptoms in MRL/lpr mice, respectively. Moreover, we showed that the attenuated disease phenotype could be recapitulated with a single antibiotic vancomycin, which reshaped the gut microbiota and changed microbial functional pathways in a time-dependent manner. Furthermore, vancomycin treatment increased the barrier function of the intestinal epithelium, thus preventing the translocation of lipopolysaccharide, a cell wall component of Gram-negative Proteobacteria and known inducer of lupus in mice, into the circulation. These results suggest that mixed antibiotics or a single antibiotic vancomycin ameliorate SLE-like disease in MRL/lpr mice by changing the composition of gut microbiota.en
dc.description.sponsorshipThis work was support by NIH grants AR067418 and AI117597en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/s41598-017-14223-0en
dc.identifier.urihttp://hdl.handle.net/10919/80362en
dc.identifier.volume7en
dc.language.isoenen
dc.publisherNatureen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleAntibiotics ameliorate lupus-like symptoms in miceen
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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