Comparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiae

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dc.contributor.authorWei, Yunen
dc.contributor.authorCheng, Biaoen
dc.contributor.authorZhu, Guodingen
dc.contributor.authorShen, Danyuen
dc.contributor.authorLiang, Jiangtaoen
dc.contributor.authorWang, Congen
dc.contributor.authorWang, Jingen
dc.contributor.authorTang, Jianxiaen
dc.contributor.authorCao, Junen
dc.contributor.authorSharakhov, Igor V.en
dc.contributor.authorXia, Aien
dc.contributor.departmentEntomologyen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.date.accessioned2018-01-02T23:00:55Zen
dc.date.available2018-01-02T23:00:55Zen
dc.date.issued2017-06-05en
dc.description.abstractBackground Anopheles sinensis is a dominant natural vector of Plasmodium vivax in China, Taiwan, Japan, and Korea. Recent genome sequencing of An. sinensis provides important insights into the genomic basis of vectorial capacity. However, the lack of a physical genome map with chromosome assignment and orientation of sequencing scaffolds hinders comparative analyses with other genomes to infer evolutionary changes relevant to the vector capacity. Results Here, a physical genome map for An. sinensis was constructed by assigning 52 scaffolds onto the chromosomes using fluorescence in situ hybridization (FISH). This chromosome-based genome assembly composes approximately 36% of the total An. sinensis genome. Comparisons of 3955 orthologous genes between An. sinensis and Anopheles gambiae identified 361 conserved synteny blocks and 267 inversions fixed between these two lineages. The rate of gene order reshuffling on the X chromosome is approximately 3.2 times higher than that on the autosomes. Conclusions The physical map will facilitate detailed genomic analysis of An. sinensis and contribute to understanding of the patterns and mechanisms of large-scale genome rearrangements in anopheline mosquitoes.en
dc.description.versionPublished versionen
dc.format.extent10 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMalaria Journal. 2017 Jun 05;16(1):235en
dc.identifier.doihttps://doi.org/10.1186/s12936-017-1888-7en
dc.identifier.issn1475-2875en
dc.identifier.orcidSharakhov, IV [0000-0003-0752-3747]en
dc.identifier.urihttp://hdl.handle.net/10919/81471en
dc.identifier.volume16en
dc.language.isoenen
dc.publisherBiomed Centralen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000403851200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderThe Author(s)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectInfectious Diseasesen
dc.subjectParasitologyen
dc.subjectTropical Medicineen
dc.subjectChromosomal evolutionen
dc.subjectGRIMMen
dc.subjectInversion fixationen
dc.subjectFluorescence in situ hybridizationen
dc.subjectOrthoDBen
dc.subjectSynteny blocksen
dc.subjectDIPTERA-CULICIDAEen
dc.subjectPLASMODIUM-VIVAXen
dc.subjectGENUS ANOPHELESen
dc.subjectCENTRAL CHINAen
dc.subjectMOSQUITOen
dc.subjectSEQUENCEen
dc.subjectREARRANGEMENTSen
dc.subjectCHROMOSOMESen
dc.subjectEVOLUTIONen
dc.subjectSTEPHENSIen
dc.titleComparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiaeen
dc.title.serialMalaria Journalen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Entomologyen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Fralin Affiliated Facultyen

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