Synthesis, cytotoxicity, and hydroxyapatite formation in 27-Tris-SBF for sol-gel based CaO-P2O5-SiO2-B2O3-ZnO bioactive glasses

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dc.contributor.authorKaur, G.en
dc.contributor.authorPickrell, Gary R.en
dc.contributor.authorKimsawatde, Gade C.en
dc.contributor.authorAllbee, H. A.en
dc.contributor.authorSriranganathan, Nammalwaren
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.contributor.departmentMaterials Science and Engineering (MSE)en
dc.date.accessioned2017-03-07T15:35:00Zen
dc.date.available2017-03-07T15:35:00Zen
dc.date.issued2014-03-18en
dc.description.abstractCaO-P2O5-SiO2-B2O3-ZnO bioactive glasses were prepared via an optimized sol-gel method. The current investigation was focused on producing novel zinc based calcium phosphoborosilicate glasses and to evaluate their mechanical, rheological, and biocompatible properties. The morphology and composition of these glasses were studied using X-ray diffraction (XRD) and scanning electron microscopy (SEM). The particle size, mechanical and flexural strength was also determined. Furthermore, the zeta potential of all the glasses were determined to estimate their flocculation tendency. The thermal analysis and weight loss measurements were carried out using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) respectively. For assessing the in-vitro bioactive character of synthesized glasses, the ability for apatite formation on their surface upon their immersion in simulated body fluid (SBF) was checked using SEM and pH measurements. MTS assay cytotoxicity assay and live-dead cell viability test were conducted on J774A.1 cells murine macrophage cells for different glass concentrations.en
dc.description.versionPublished versionen
dc.format.extent? - ? (14) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKaur, G.; Pickrell, G.; Kimsawatde, G.; Homa, D.; Allbee, H. A.; Sriranganathan, N., "Synthesis, cytotoxicity, and hydroxyapatite formation in 27-Tris-SBF for sol-gel based CaO-P2O5-SiO2-B2O3-ZnO bioactive glasses," Scientific Reports 4:4392, (2014). DOI: 10.1038/srep04392.en
dc.identifier.doihttps://doi.org/10.1038/srep04392en
dc.identifier.issn2045-2322en
dc.identifier.orcidPickrell, G [0000-0003-1782-9010]en
dc.identifier.urihttp://hdl.handle.net/10919/75294en
dc.identifier.volume4en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000332937300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Unporteden
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en
dc.subjectIN-VITRO BIOACTIVITYen
dc.subjectIONIC-STRENGTHen
dc.subjectZINCen
dc.subjectTEMPERATUREen
dc.subjectCERAMICSen
dc.subjectVIVOen
dc.subjectNANOPARTICLESen
dc.subjectBIOCERAMICSen
dc.subjectSCAFFOLDSen
dc.subjectKINETICSen
dc.titleSynthesis, cytotoxicity, and hydroxyapatite formation in 27-Tris-SBF for sol-gel based CaO-P2O5-SiO2-B2O3-ZnO bioactive glassesen
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineeringen
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineering/Materials Science and Engineeringen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen

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