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Modeling human enteric dysbiosis and rotavirus immunity in gnotobiotic pigs. [poster]

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dc.contributor.authorTwitchell, Ericaen
dc.contributor.authorTin, Christineen
dc.contributor.authorWen, Keen
dc.contributor.authorZhang, Husenen
dc.contributor.authorBecker-Dreps, Sylviaen
dc.contributor.authorAzcarate-Peril, M. Andreaen
dc.contributor.authorVilchez, Samuelen
dc.contributor.authorLi, Guohuaen
dc.contributor.authorRamesh, Ashwinen
dc.contributor.authorWeiss, Mariahen
dc.contributor.authorLei, Shaohuaen
dc.contributor.authorBui, Tammyen
dc.contributor.authorYang, Xingdongen
dc.contributor.authorSchultz-Cherry, Stacey L.en
dc.contributor.authorYuan, Lijuanen
dc.date.accessioned2017-02-23T15:14:04Zen
dc.date.available2017-02-23T15:14:04Zen
dc.date.issued2016-12en
dc.description.abstractBackground Oral vaccines, such as those for rotavirus are less efficacious in children from underdeveloped regions, where most severe disease occurs, than in children from more affluent areas. This disparity may be due to altered gut microbiota composition (dysbiosis), environmental enteropathy (EE), high maternal antibody titers, malnutrition, or influence of concurrent enteropathogens. Composition of gut microbiota in children is influenced by method of delivery, environmental hygiene and nutritional status. Studies have shown composition of gut microbiota to be significantly different between African and northern European infants and between malnourished and well-nourished children. A recent study has shown that EE was associated with failure of the oral rotavirus vaccine Rotarix, and underperformance of the oral polio vaccine. An animal model to study the effects of enteric dysbiosis on oral vaccine immunity is needed to evaluate potential treatments to reverse the dysbiosis and/or improve vaccine efficacy. Pigs and humans have similar immune systems, high genomic and protein sequence homology, omnivorous diet, and colonic fermentation, making pigs valuable models in biomedical research. The neonatal gnotobiotic (Gn) pig is a well-established model of human rotavirus disease and immunity.en
dc.format.mimetypeapplication/pdfen
dc.identifier.orcidYuan, L [0000-0003-0709-5228]en
dc.identifier.urihttp://hdl.handle.net/10919/75135en
dc.language.isoenen
dc.relation.ispartofThe American College of Veterinary Pathologists Annual meetingen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectenteric dysbiosisen
dc.subjectrotavirusen
dc.subjectimmuityen
dc.subjectgnotobiotic pigen
dc.titleModeling human enteric dysbiosis and rotavirus immunity in gnotobiotic pigs. [poster]en
dc.typePosteren
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen

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