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Effect of Salmonella enterica serovar Typhimurium VNP20009 and VNP20009 with restored chemotaxis on 4T1 mouse mammary carcinoma progression

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dc.contributor.authorCoutermarsh-Ott, Sherylen
dc.contributor.authorBroadway, Katherine M.en
dc.contributor.authorScharf, Birgit E.en
dc.contributor.authorAllen, Irving C.en
dc.contributor.departmentBiological Sciencesen
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.contributor.departmentVirginia-Maryland College of Veterinary Medicineen
dc.date.accessioned2017-12-18T17:36:17Zen
dc.date.available2017-12-18T17:36:17Zen
dc.date.issued2017-05-16en
dc.description.abstractA variety of bacterial strains have been evaluated as bio-therapeutic and immunomodulatory agents to treat cancer. One such strain, Salmonella enterica serovar Typhimurium VNP20009, which is attenuated by a purine auxotrophic mutation and modified lipid A, is characterized in previous models as a safely administered, tumor colonizing agent. However, earlier work tended to use less aggressive cancer cell lines and immunocompromised animal models. Here, we investigated the safety and efficacy of VNP20009 in a highly malignant murine model of human breast cancer. Additionally, as VNP20009 has recently been found to have a defective chemotaxis system, we tested whether restoring chemotaxis would improve anti-cancer properties in this model system. Exposure to VNP20009 had no significant effect on primary mammary tumor size or pulmonary metastasis, and the tumor colonizing process appeared chemotaxis independent. Moreover, tumor-bearing mice exposed to Salmonella exhibited increased morbidity that was associated with significant liver disease. Our results suggest that VNP20009 may not be safe or efficacious when used in aggressive, metastatic breast cancer models utilizing immunocompetent animals.en
dc.description.versionPublished versionen
dc.format.extent33601 - 33613 (13) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.18632/oncotarget.16830en
dc.identifier.issn1949-2553en
dc.identifier.issue20en
dc.identifier.orcidScharf, BE [0000-0001-6271-8972]en
dc.identifier.orcidAllen, IC [0000-0001-9573-5250]en
dc.identifier.urihttp://hdl.handle.net/10919/81264en
dc.identifier.volume8en
dc.language.isoenen
dc.publisherImpact Journalsen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000401767700099&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectOncologyen
dc.subjectCell Biologyen
dc.subjectbacterial therapeuticen
dc.subjectbreast canceren
dc.subjectchemotaxisen
dc.subjectCheYen
dc.subjectmetastasisen
dc.subjectNUDE-MICEen
dc.subjectATTENUATED SALMONELLAen
dc.subjectSOLID TUMORSen
dc.subjectCANCER METASTASISen
dc.subjectTARGETED THERAPYen
dc.subjectANTITUMOR AGENTen
dc.subjectPHASE-Ien
dc.subjectMODELSen
dc.subjectA1-Ren
dc.subjectEFFICACYen
dc.titleEffect of Salmonella enterica serovar Typhimurium VNP20009 and VNP20009 with restored chemotaxis on 4T1 mouse mammary carcinoma progressionen
dc.title.serialOncoTargeten
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Biological Sciencesen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Fralin Affiliated Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen

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