Chronic stress, epigenetics, and adipose tissue metabolism in the obese state

dc.contributor.authorXiao, Yangen
dc.contributor.authorLiu, Dongminen
dc.contributor.authorCline, Mark A.en
dc.contributor.authorGilbert, Elizabeth R.en
dc.date.accessioned2020-10-26T13:06:36Zen
dc.date.available2020-10-26T13:06:36Zen
dc.date.issued2020-10-19en
dc.date.updated2020-10-25T04:15:20Zen
dc.description.abstractIn obesity, endocrine and metabolic perturbations, including those induced by chronic activation of the hypothalamus–pituitary–adrenal axis, are associated with the accumulation of adipose tissue and inflammation. Such changes are attributable to a combination of genetic and epigenetic factors that are influenced by the environment and exacerbated by chronic activation of the hypothalamus–pituitary–adrenal axis. Stress exposure at different life stages can alter adipose tissue metabolism directly through epigenetic modification or indirectly through the manipulation of hypothalamic appetite regulation, and thereby contribute to endocrine changes that further disrupt whole-body energy balance. This review synthesizes current knowledge, with an emphasis on human clinical trials, to describe metabolic changes in adipose tissue and associated endocrine, genetic and epigenetic changes in the obese state. In particular, we discuss epigenetic changes induced by stress exposure and their contribution to appetite and adipocyte dysfunction, which collectively promote the pathogenesis of obesity. Such knowledge is critical for providing future directions of metabolism research and targets for treating metabolic disorders.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationNutrition & Metabolism. 2020 Oct 19;17(1):88en
dc.identifier.doihttps://doi.org/10.1186/s12986-020-00513-4en
dc.identifier.urihttp://hdl.handle.net/10919/100701en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderThe Author(s)en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleChronic stress, epigenetics, and adipose tissue metabolism in the obese stateen
dc.title.serialNutrition & Metabolismen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
12986_2020_Article_513.pdf
Size:
922.26 KB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description: