The purpose of this study was to synthesize research as it relates to brain-based learning and its relevance to the agricultural education profession. Through a comprehensive literature review, brainbased studies were analyzed to create a historical timeline of the discipline, investigate teaching principles, articulate relevance, and identify potential future implications for agricultural education. The holistic approach to learning in agricultural education programs presents a ripe environment for action research with brain-based learning practices. Professional development with agricultural educators may be needed to further encourage and support comprehensive studies that investigate the precepts of brain-based learning.