A VP26-mNeonGreen Capsid Fusion HSV-2 Mutant Reactivates from Viral Latency in the Guinea Pig Genital Model with Normal Kinetics

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dc.contributor.authorPieknik, J. R.en
dc.contributor.authorBertke, Andrea S.en
dc.contributor.authorTang, S.en
dc.contributor.authorKrause, P. R.en
dc.date.accessioned2018-09-15T13:51:07Zen
dc.date.available2018-09-15T13:51:07Zen
dc.date.issued2018-05-01en
dc.description.abstractFluorescent herpes simplex viruses (HSV) are invaluable tools for localizing virus in cells, permitting visualization of capsid trafficking and enhancing neuroanatomical research. Fluorescent viruses can also be used to study virus kinetics and reactivation in vivo. Such studies would be facilitated by fluorescent herpes simplex virus recombinants that exhibit wild-type kinetics of replication and reactivation and that are genetically stable. We engineered an HSV-2 strain expressing the fluorescent mNeonGreen protein as a fusion with the VP26 capsid protein. This virus has normal replication and in vivo recurrence phenotypes, providing an essential improved tool for further study of HSV-2 infection.en
dc.description.versionPublished versionen
dc.format.extent13 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationPieknik, J.R.; Bertke, A.S.; Tang, S.; Krause, P.R. A VP26-mNeonGreen Capsid Fusion HSV-2 Mutant Reactivates from Viral Latency in the Guinea Pig Genital Model with Normal Kinetics. Viruses 2018, 10, 246.en
dc.identifier.doihttps://doi.org/10.3390/v10050246en
dc.identifier.issn1999-4915en
dc.identifier.issue5en
dc.identifier.orcidBertke, AS [0000-0002-8941-8010]en
dc.identifier.urihttp://hdl.handle.net/10919/85023en
dc.identifier.volume10en
dc.language.isoenen
dc.publisherMDPIen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000435198000031&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectVirologyen
dc.subjectHSV-2en
dc.subjectreactivationen
dc.subjectguinea pigen
dc.subjectfluorescent HSV-2en
dc.subjectmNeonGreenen
dc.subjectvaginal infection modelen
dc.subjectHERPES-SIMPLEX-VIRUSen
dc.subjectGREEN FLUORESCENT PROTEINen
dc.subjectIN-VIVOen
dc.subjectREPLICATIONen
dc.subjectINFECTIONen
dc.subjectLOCALIZATIONen
dc.subjectTRANSPORTen
dc.subjectENVELOPEen
dc.subjectTEGUMENTen
dc.subjectGANGLIAen
dc.titleA VP26-mNeonGreen Capsid Fusion HSV-2 Mutant Reactivates from Viral Latency in the Guinea Pig Genital Model with Normal Kineticsen
dc.title.serialVirusesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Fralin Affiliated Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Population Health Sciencesen

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