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dc.contributor.authorWilson, Nina M.
dc.contributor.authorMcMaster, Nicole
dc.contributor.authorGantulga, Dash
dc.contributor.authorSoyars, Cara
dc.contributor.authorMcCormick, Susan P.
dc.contributor.authorKnott, Ken
dc.contributor.authorSenger, Ryan S.S
dc.contributor.authorSchmale, David G. III
dc.date.accessioned2018-01-15T18:24:38Z
dc.date.available2018-01-15T18:24:38Z
dc.date.issued2017-04-01
dc.identifier.citationWilson, N.M.; McMaster, N.; Gantulga, D.; Soyars, C.; McCormick, S.P.; Knott, K.; Senger, R.S.; Schmale, D.G. Modification of the Mycotoxin Deoxynivalenol Using Microorganisms Isolated from Environmental Samples. Toxins 2017, 9, 141.
dc.identifier.issn2072-6651en_US
dc.identifier.urihttp://hdl.handle.net/10919/81784
dc.description.abstractThe trichothecene mycotoxin deoxynivalenol (DON) is a common contaminant of wheat, barley, and maize. New strategies are needed to reduce or eliminate DON in feed and food products. Microorganisms from plant and soil samples collected in Blacksburg, VA, USA, were screened by incubation in a mineral salt media containing 100 μg/mL DON and analysis by gas chromatography mass spectrometry (GC/MS). Two mixed cultures derived from soil samples consistently decreased DON levels in assays using DON as the sole carbon source. Nuclear magnetic resonance (NMR) analysis indicated that 3-keto-4-deoxynivalenol was the major by-product of DON. Via 16S rRNA sequencing, these mixed cultures, including mostly members of the genera Acinetobacter, Leadbetterella, and Gemmata, were revealed. Incubation of one of these mixed cultures with wheat samples naturally contaminated with 7.1 μg/mL DON indicated nearly complete conversion of DON to the less toxic 3-epimer-DON (3-epi-DON). Our work extends previous studies that have demonstrated the potential for bioprospecting for microorganisms from the environment to remediate or modify mycotoxins for commercial applications, such as the reduction of mycotoxins in fuel ethanol co-products.
dc.format.extent? - ? (11) page(s)en_US
dc.format.mimetypeapplication/pdf
dc.languageen_USen_US
dc.publisherMDPI
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000404136900031&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en_US
dc.rightsCreative Commons Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectFood Toxicologyen_US
dc.subjectmycotoxinen_US
dc.subjecttrichotheceneen_US
dc.subjectdeoxynivalenolen_US
dc.subjectbioprospectingen_US
dc.subjectdetoxificationen_US
dc.subjectFusariumen_US
dc.subjectTRICHOTHECENE MYCOTOXINSen_US
dc.subjectMICROBIAL DETOXIFICATIONen_US
dc.subjectWORLDWIDE CONTAMINATIONen_US
dc.subjectFUSARIUM MYCOTOXINSen_US
dc.subjectDEGRADATIONen_US
dc.subjectGRAINSen_US
dc.subject3-EPI-DEOXYNIVALENOLen_US
dc.subjectTRANSFORMATIONen_US
dc.subjectOCHRATOXINen_US
dc.subjectTOXICOLOGYen_US
dc.titleModification of the Mycotoxin Deoxynivalenol Using Microorganisms Isolated from Environmental Samplesen_US
dc.typeArticle - Refereeden_US
dc.description.versionPublished (Publication status)en_US
dc.title.serialToxins
dc.identifier.doihttps://doi.org/10.3390/toxins9040141
dc.identifier.volume9en_US
dc.identifier.issue4en_US
dc.identifier.orcidSchmale, DG [0000-0002-7003-7429]en_US
dc.type.dcmitypeText
pubs.organisational-group/Virginia Tech
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Biological Systems Engineering
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Faculty
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Plant Pathology, Physiology, & Weed Science
pubs.organisational-group/Virginia Tech/All T&R Faculty
pubs.organisational-group/Virginia Tech/University Research Institutes
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Fralin Affiliated Faculty


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Creative Commons Attribution 4.0 International
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