Early influences of microbiota on white matter development in germ-free piglets

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dc.contributor.authorAhmed, Sadiaen
dc.contributor.authorTravis, Sierrahen
dc.contributor.authorDíaz-Bahamonde, Franciscaen
dc.contributor.authorPorter, Demishaen
dc.contributor.authorHenry, Saraen
dc.contributor.authorRavipati, Adityaen
dc.contributor.authorBooker, Arynen
dc.contributor.authorDing, Hanzhangen
dc.contributor.authorJu, Jingen
dc.contributor.authorRamesh, Ashwinen
dc.contributor.authorPickrell, Alicia M.en
dc.contributor.authorWang, Maosenen
dc.contributor.authorLaConte, Stephen M.en
dc.contributor.authorHowell, Brittany R.en
dc.contributor.authorYuan, Lijuanen
dc.contributor.authorMorton, Paul D.en
dc.date.accessioned2021-12-30T17:46:41Zen
dc.date.available2021-12-30T17:46:41Zen
dc.date.issued2021-12-27en
dc.date.updated2021-12-30T17:46:30Zen
dc.description.abstractAbnormalities in the prefrontal cortex (PFC), as well as the underlying white matter (WM) tracts, lie at the intersection of many neurodevelopmental disorders. The influence of microorganisms on brain development has recently been brought into the clinical and research spotlight as alterations in commensal microbiota are implicated in such disorders, including autism spectrum disorders, schizophrenia, depression, and anxiety via the gut-brain axis. In addition, gut dysbiosis is common in preterm birth patients who often display diffuse WM injury and delayed WM maturation in critical tracts including those within the PFC and corpus callosum. Microbial colonization of the gut aligns with ongoing postnatal processes of oligodendrogenesis and the peak of brain myelination in humans; however, the influence of microbiota on gyral WM development remains elusive. Here, we develop and validate a neonatal germ-free swine model to address these issues, as piglets share key similarities in WM volume, developmental trajectories, and distribution to humans. We find significant region-specific reductions, and sexually dimorphic trends, in WM volume, oligodendrogenesis, and mature oligodendrocyte numbers in germ-free piglets during a key postnatal epoch of myelination. Our findings indicate that microbiota plays a critical role in promoting WM development during early life when the brain is vulnerable to environmental insults that can result in an array of disabilities manifesting later in life.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fncel.2021.807170en
dc.identifier.eissn1662-5102en
dc.identifier.orcidPickrell, Alicia [0000-0002-8470-6056]en
dc.identifier.orcidMorton, Paul [0000-0002-3657-0115]en
dc.identifier.orcidYuan, Lijuan [0000-0003-0709-5228]en
dc.identifier.urihttp://hdl.handle.net/10919/107293en
dc.identifier.volume15en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subject0601 Biochemistry and Cell Biologyen
dc.subject1109 Neurosciencesen
dc.titleEarly influences of microbiota on white matter development in germ-free pigletsen
dc.title.serialFrontiers in Cellular Neuroscienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dcterms.dateAccepted2021-11-29en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiologyen
pubs.organisational-group/Virginia Tech/University Research Institutesen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciencesen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Durelle Scotten
pubs.organisational-group/Virginia Tech/Science/School of Neuroscienceen

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