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Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2

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dc.contributor.authorChuong, Christinaen
dc.contributor.authorDuChane, Christine M.en
dc.contributor.authorWebb, Emily M.en
dc.contributor.authorRai, Pallavien
dc.contributor.authorMarano, Jeffrey M.en
dc.contributor.authorBernier, Chad M.en
dc.contributor.authorMerola, Joseph S.en
dc.contributor.authorWeger-Lucarelli, Jamesen
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.contributor.departmentChemistryen
dc.contributor.departmentEntomologyen
dc.contributor.departmentTranslational Biology, Medicine and Healthen
dc.date.accessioned2021-06-10T19:35:03Zen
dc.date.available2021-06-10T19:35:03Zen
dc.date.issued2021-05-25en
dc.date.updated2021-06-10T13:45:55Zen
dc.description.abstractSARS-CoV-2 emerged in 2019 as a devastating viral pathogen with no available preventative or treatment to control what led to the current global pandemic. The continued spread of the virus and increasing death toll necessitate the development of effective antiviral treatments to combat this virus. To this end, we evaluated a new class of organometallic complexes as potential antivirals. Our findings demonstrate that two pentamethylcyclopentadienyl (Cp*) rhodium piano stool complexes, Cp*Rh(1,3-dicyclohexylimidazol-2-ylidene)Cl<sub>2</sub> (complex 2) and Cp*Rh(dipivaloylmethanato)Cl (complex 4), have direct virucidal activity against SARS-CoV-2. Subsequent in vitro testing suggests that complex 4 is the more stable and effective complex and demonstrates that both 2 and 4 have low toxicity in Vero E6 and Calu-3 cells. The results presented here highlight the potential application of organometallic complexes as antivirals and support further investigation into their activity.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationChuong, C.; DuChane, C.M.; Webb, E.M.; Rai, P.; Marano, J.M.; Bernier, C.M.; Merola, J.S.; Weger-Lucarelli, J. Noble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2. Viruses 2021, 13, 980.en
dc.identifier.doihttps://doi.org/10.3390/v13060980en
dc.identifier.urihttp://hdl.handle.net/10919/103760en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectSARS-CoV-2en
dc.subjectCOVID-19en
dc.subjectorganometallicsen
dc.subjectmetallodrugsen
dc.subjectantiviralen
dc.subjectvirucidalen
dc.titleNoble Metal Organometallic Complexes Display Antiviral Activity against SARS-CoV-2en
dc.title.serialVirusesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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